Loading...

Enhanced Electron Transfer Mediated by Conjugated Polyelectrolyte and Its Application to Washing-Free DNA Detection

Extra Form
author Han Young Woo
Homepage http://Journal of the American Chemical ...s.7b12382)
journal http://www.ooml.korea.ac.kr
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print

정지은.jpg

Ji-Eun Jeong (박사과정)

 

Direct electron transfer between a redox label and an electrode requires a very short working distance (<1-2 nm), and in general an affinity biosensor based on the direct electron transfer requires a finely smoothed Au electrode surface to support efficient target binding. Here, we report that direct electron transfer over a longer working distance is possible between (i) an anionic p-conjugated polyelectrolyte (CPE) label having many redox-active sites and (ii) a readily prepared, thin polymeric monolayer-modified indium-tin oxide (ITO) electrode. In addition, the long and flexible CPE label (~18 nm for 10 kDa) can approach the electrode within the working distance after sandwich-type target-specific binding, and fast CPE-mediated oxidation of ammonia-borane along the entire CPE backbone affords high signal amplification. Negatively charged casein and hydrophilic side chains of the CPE minimize nonspecific adsorption of a CPE-labeled DNA onto the ITO electrode. All are beneficial for sensitive washing-free DNA detection.

 

toc.gif

 

https://pubs.acs.org/doi/abs/10.1021/jacs.7b12382


  1. Harnessing Intramolecular Rotation to Enhance Two‐photon Imaging of Aβ Plaques Through Minimizing Background Fluorescence

    Jong Seung Kim
    http://orgchem.korea.ac.kr
    Jinwoo Shin(제1저자 석박통합과정) The aggregation of Aβ‐proteins in senile plaques is a critical event during the development of Alzheimer’s disease, and the postmortem detection of Aβ‐rich proteinaceous deposits via fluores...
    Date2019.03.18 Bywebmaster Views543
    Read More
  2. Proteogenomic Characterization of Human Early-Onset Gastric Cancer

    Sang-Won Lee
    http://ionchem.korea.ac.kr/
    Dong-Gi Mun(제1저자, 박사과정) We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation co...
    Date2019.01.21 Bywebmaster Views250
    Read More
  3. Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over-Expressing NQO1

    Jong Seung Kim
    http://orgchem.korea.ac.kr
    Activatable (turn-on) probes that permit the rapid, sensitive, selective, and accurate identification of cancer-associated biomarkers can help drive advances in cancer research. Herein, a NAD(P)H:quinone oxidoreductase- 1 (NQO1)-specific ch...
    Date2019.01.11 Bywebmaster Views597
    Read More
  4. Molecularly Controlled Stark Effect Induces Significant Rectification in Polycyclic Aromatic Hydrocarbon-terminated n-Alkanethiolates

    Hyo Jae Yoon
    https://hyojaeyoon.wixsite.com/omml
    Soo Jin Cho(제1저자, 석박통합과정) Gyu Don Kong(공동 제1저자, 박사과정) Variation of electronic structure of individual molecules as a function of applied bias matters for performance of molecular and organic electronic devices. Understandi...
    Date2018.12.26 Bywebmaster Views421
    Read More
  5. A New Approach for Large-Area Thermoelectric Junctions with Liquid Eutectic Gallium-Indium Electrode

    Hyo Jae Yoon
    https://hyojaeyoon.wixsite.com/omml
    Sohyun Park(통합과정) A challenge in organic thermoelectrics is to relate thermoelectric performance of devices to the chemical and electronic structures of organic component inside them on a molecular scale. To this end, a reliable and rep...
    Date2018.11.13 Bywebmaster Views796
    Read More
  6. Nanometric Water Channels in Water-in-Salt Lithium Ion Battery Electrolyte

    Kyungwon Kwak and Minhaeng Cho
    https://cmsd.ibs.re.kr/html/cmsd_en/
    Joonhyung Lim(박사과정) Lithium-ion batteries (LIBs) have been deployed in a wide range of energy-storage applications and helped to revolutionize technological development. Recently, a lithium ion battery that uses superconcentrated salt w...
    Date2018.11.12 Bywebmaster Views520
    Read More
  7. Topotactic Transformations in an Icosahedral Nanocrystal to Form Efficient Water-Splitting Catalysts

    Kwangyeol Lee
    http://nanolab.korea.ac.kr/
    Designing high‐performance, precious‐metal‐based, and economic electrocatalysts remains an important challenge in proton exchange membrane (PEM) electrolyzers. Here, a highly active and durable bifunctional electrocatalyst for PEM electroly...
    Date2018.11.12 Bywebmaster Views758
    Read More
  8. Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions

    Sang-Hee Shim and Minhaeng Cho
    https://cmsd.ibs.re.kr/html/cmsd_en/
    Euihyun Lee(박사과정) Fluorescent proteins contain an internal chromophore constituted of amino acids or an external chromophore covalently bonded to the protein. To increase their fluorescence intensities, many research groups have attempt...
    Date2018.11.12 Bywebmaster Views413
    Read More
  9. Elucidating the Role of Molecule-Electrode Interfacial Defects in Charge Tunneling Characteristics of Large-area Junctions

    Hyo Jae Yoon
    https://hyojaeyoon.wixsite.com/omml
    Gyu Don Kong(박사과정) Junji Jin(석사과정) Interfacial chemistry at organic-inorganic contact critically determines function of a wide range of molecular and organic electronic devices and other systems. The chemistry is, however, difficult...
    Date2018.11.12 Bywebmaster Views425
    Read More
  10. PDMS-Coated Hypercrosslinked Porous Organic Polymers Modified via Double Postsynthetic Acidifications for Ammonia Capture

    Chang Seop Hong
    https://www.immlab.korea.ac.kr/
    Dong Won Kang(통합과정) Minjung Kang(통합과정) A hypercrosslinked porous organic polymer was modified by post-oxidation and post-sulfonation to obtain a porous platform with high density of acidic groups. Such acidified material exhibits re...
    Date2018.11.12 Bywebmaster Views2322
    Read More
  11. Accurate Quantification of N-glycolylneuraminic Acid in Therapeutic Proteins Using Supramolecular Mass Spectrometry

    Hugh I. Kim
    https://sites.google.com/site/hughkimgroup/
    Hyun Hee Lee (박사과정) Chae Eun Heo (박사과정) Practical applications of innovative host-guest systems are challenging because of unexpected guest competitors and/or subtle environmental differences. Herein, a supramolecular mass spectrome...
    Date2018.11.12 Bywebmaster Views333
    Read More
  12. Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug

    Jong Seung Kim
    http://orgchem.korea.ac.kr/
    Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here we report a new approach to overcoming resistance that involves re...
    Date2018.11.12 Bywebmaster Views510
    Read More
  13. Janus Nanoparticle Structural Motif Control via Asymmetric Cation Exchange in Edge-Protected Cu1.81S@IrxSy Hexagonal Nanoplates

    Kwangyeol Lee
    http://nanolab.korea.ac.kr/
    Post-synthetic transformation of nanoparticles has received great attention, because this approach can provide an unusual route to elaborately composition-controlled nanostructures while maintaining the overall structure of the template. In...
    Date2018.11.12 Bywebmaster Views519
    Read More
  14. Deconvolution of Tunneling Current in Large-area Junctions Formed with Mixed Self-Assembled Monolayers

    Hyo Jae Yoon
    https://hyojaeyoon.wixsite.com/omml
    Junji Jin(석사과정) Gyu Don Kong(박사과정) Whereas single-component self-assembled monolayers (SAMs) have served widely as organic components in molecular and organic electronics, how the performance of the device is influenced by the hetero...
    Date2018.11.12 Bywebmaster Views420
    Read More
  15. Electron heating and thermal relaxation of gold nanorods revealed by two-dimensional electronic spectroscopy

    Minhaeng Cho
    http://cmsd.ibs.re.kr/html/cmsd_en/
    To elucidate the complex interplay between the size and shape of gold nanorods and their electronic, photothermal, and optical properties for molecular imaging, photothermal therapy, and optoelectronic devices, it is a prerequisite to chara...
    Date2018.11.12 Bywebmaster Views579
    Read More
  16. (Semi)ladder-Type Bithiophene Imide-Based All-Acceptor Semiconductors: Synthesis, Structure–Property Correlations, and Unipolar n-Type Transistor Performance

    Han Young Woo
    http://www.ooml.korea.ac.kr/
    Development of high-performance unipolar n-type organic semiconductors still remains as a great challenge. In this work, all-acceptor bithiophene imide-based ladder-type small molecules BTIn and semiladder-type homopolymers PBTIn (n = 1&nda...
    Date2018.11.12 Bywebmaster Views429
    Read More
  17. Dendrite-Embedded Platinum–Nickel Multiframes as Highly Active and Durable Electrocatalyst toward the Oxygen Reduction Reaction

    Kwangyeol Lee
    http://nanolab.korea.ac.kr/
    Hyukbu Kwon (석사과정) Jongsik Park (박사과정) Pt-based nanoframe catalysts have been explored extensively due to their superior activity toward the oxygen reduction reaction (ORR). Herein, we report the synthesis of Pt–Ni multiframes...
    Date2018.11.12 Bywebmaster Views465
    Read More
  18. Mid-Infrared Intraband Transition of Metal Excess Colloidal Ag2Se Nanocrystals

    Kwang Seob Jeong
    https://kwangsjeong.wixsite.com/ksjlab-koreauniv
    Mihyeon Park (석사과정) Dongsun Choi (박사과정) Steady-state intraband transition, which is a promising electronic transition of a colloidal quantum dot along with the band-gap transition, had been a long-standing challenge. The steady-stat...
    Date2018.11.12 Bywebmaster Views550
    Read More
  19. Enhanced Electron Transfer Mediated by Conjugated Polyelectrolyte and Its Application to Washing-Free DNA Detection

    Han Young Woo
    http://Journal of the American Chemical Society. 2017. Article ASAP (DOI: 10.1021/jacs.7b12382)
    Ji-Eun Jeong (박사과정) Direct electron transfer between a redox label and an electrode requires a very short working distance (<1-2 nm), and in general an affinity biosensor based on the direct electron transfer requires a finely smoothed ...
    Date2018.02.20 ByManager Views1297
    Read More
  20. Vertex-reinforced PtCuCo ternary nanoframes as efficient and stable electrocatalysts for the oxygen reduction reaction and the methanol oxidation reaction

    Kwangyeol Lee
    http://nanolab.korea.ac.kr/
    Taehyun Kwon(박사과정) / Minki Jun (박사과정) Noble metal binary alloy nanoframes have emerged as a new class of fuel cell electrocatalysts because of their intrinsic high catalytic surface area and accompanied high catalytic activity. Howe...
    Date2018.02.20 ByManager Views1202
    Read More
Board Pagination ‹ Prev 1 2 3 4 5 6 7 8 Next ›
/ 8

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Department of Chemistry, Korea University, Tel) +82-2-3290-3120
145 Anam-ro Seongbuk-gu Seoul, 02841, Republic of Korea
Copyright(c) 2014 KOREA UNIVERSITY DEPARTMENT of CHEMISTRY. All right reserved.