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2019.02.28 09:44

[March 5. 2019] Prof. Michael J. Sailor/Treatment of S. aureus Bacterial Infections with Porous Silicon Nanoparticles

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Speaker Prof. Michael J. Sailor (UC San Diego)
Date Tuesday. 5 March. 2019
Time 5:00pm
Venue #331. Asan Hall. College of Science

 

Treatment of S. aureus Bacterial

Infections with Porous Silicon

Nanoparticles

 

 The use of porous silicon nanoparticles for peptide-targeted delivery of therapeutic payloads and for luminescence imaging will be described. One area where there is clearly an unmet therapeutic need is in the treatment of antibiotic-resistant bacterial infections, and the deployment of porous silicon nanoparticles to meet this challenge will be described. Porous Si nanoparticles can be simultaneously loaded and sealed using aqueous solutions of the desired therapeutic (siRNA or small molecule antibiotics will be used as examples) in the presence of calcium or magnesium ions. The resulting nanostructures consist of drug loaded into the mesopores of the nanoparticle and sealed with biodegradable calcium or magnesium silicate. Attachment of functional peptides imparts targeting and cell penetration properties to the constructs that show improved gene silencing and therapeutic outcomes in vivo . The intrinsic photoluminescence that derives from quantum confinement in the silicon skeleton provides a built-in luminescent probe that can be used for in vivo and in vitro imaging and self-reporting drug delivery in these systems.


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
56 [March 21, 2019] Nanomaterials Design for Energy Conversion and Storage Prof. Jong-Hyuk Park (Yonsei University) Thu. 21 Mar. 2019
55 [March 27, 2019] Hyperpolarization Researches with NV center, 129Xe and Parahydrogen file Prof. Keunhong Jeong March 27, 2019
54 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
53 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
» [March 5. 2019] Prof. Michael J. Sailor/Treatment of S. aureus Bacterial Infections with Porous Silicon Nanoparticles Prof. Michael J. Sailor (UC San Diego) Tuesday. 5 March. 2019
51 [Thu. 6 Dec. 2018] Prof. Dong-Ho Kim/Department of Chemistry, Yonsei University, Seoul, Korea Prof. Dong-Ho Kim (Yonsei University) Thu. 6 Dec. 2018
50 Fall semester 2018 Seminar Schedule file - -
49 [January 24, 2018] Electro-Optic Organic THz Wave Sources file Prof. O-Pil Kwon(Ajou University) January 24, 2018 (Wednesday)
48 [Thu. 30 Nov. 2017] Prof. Sunmin Ryu/Department of Chemistry, POSTECH, Pohang, South Korea Prof. Sunmin Ryu Thu. 30 Nov. 2017
47 [Thu. 23 Nov. 2017] Prof. Sung-Gon Kim/Department of Chemistry, Kyonggi University, Suwon, Korea Prof. Sung-Gon Kim Thu. 23 Nov. 2017
46 [November 14, 2017] Zero-Point Energy, Fluctuations, and Dissipation : A (Mostly) Quantum-Optical Perspective Prof. Milonni, Peter November 14, 2017
45 [Thu. 16 Nov. 2017] Prof. Hyungjun Kim/Department of Chemistry, and Graduate school of Energy, Environment, Water, and Sustainability (EEWS), KAIST, Daejeon, Korea Prof. Hyungjun Kim Thu. 16 Nov. 2017
44 [Fri. 30 Oct. 2017] Prof. Igor Rodin/Department of Chemistry, Moscow State University, Moscow, Russia Prof. Igor Rodin Fri. 30 Oct. 201
43 [October 31, 2017] New ways of vision: Protein structures in translational medicine and business development, my experience file Prof. Robert Huber(1988 Nobel Prize in Chemistry) October 31, 2017
42 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
41 [October 25, 2017] Ultrafast electron microscopy: applications in chemical and materials sciences Dr. Byung-Kuk Yoo October 25, 2017
40 [Mon. 16 Oct. 2017] Prof. Kirk S. Schanze/Department of Chemistry, University of Texas at San Antonio, Texas, USA Prof. Kirk S. Schanze Mon. 16 Oct. 2017
39 [Fri. 13 Oct. 2017] Dr. J. Nathan Hohman/The Molecular Foundry, Lawrence Berkeley National Laboratory, California, USA Dr. J. Nathan Hohman Fri. 13 Oct. 2017
38 [Thu. 12 Oct. 2017] Student Host Colloquium : Versatile Dendrimer-Encapsulated Nanoparticles for Analytical Applications Prof. Joohoon Kim Thu. 12 Oct. 2017
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