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2019.04.22 11:21

[April 25. 2019] Colorful World of Quantum Dots

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Speaker Prof. Sungjee Kim (Pohang University of Science & Technology)
Date Thu. 25 Apr. 2019
Time 5:00pm
Venue #331, Asan Hall, College of Science

 Colorful World of Quantum Dots

 

 A few imaging applications using quantum dots (QDs) will be introduced, which will cover from visible to infrared(IR) for the wavelengths and from cellular super-resolution to whole body in vivo imaging for the object scale. (1) QDs were conjugated to tumor-specific antibodies(Abs) with zwitterionic surface coating to reduce nonspecific bindings. The Ab-QD probes were used to diagnose tumors for sectioned mouse tissues, fresh mouse colons stained ex vivo and in vivo, and also for fresh human colon adenoma tissues. The probes successfully detected not only cancers that are readily discernible by bare eyes but also hyperplasia and adenoma regions. Multiplexed QD, spray-and-wash, and endoscopy approach provided a significant advantage for detecting small or flat tumors that may be missed by conventional endoscopic examinations. QD-Ab probe was also used in conjunction with a ratiometric fluorescent molecular probe, cresyl violet–glutamic acid derivative, that ratiometrically switches between two fluorescent colors in response to the enzyme activity of λ-glutamyltranspeptidase. Co-application of the two kinds of probes, QD-Abs and the ratiometric molecular probe, afforded accurate visualization of carcinomas, hyperplasia and adenoma regions. (2) Amphiphilic polyethyleneimine derivatives (amPEIs) were synthesized and used to encapsulate dozens of QDs. The QD-amPEI showed very efficient QD cellular fluorescent labeling. Co-encapsulation of QDs and oxygen sensing phosphorescence Ru dyes allowed accurate and reversible oxygen sensing capability by the ratiometric signals, which was successfully applied to cellular and spheroid models. (3) Photo-modulating QDs were designed by conjugating crystal violets (CVs) on QD surface. The QD CV conjugates (QD-CVs) shows a single cycle of emission burst as go through the stage of initially quenched off to photo-activated on and back to photo-darkened off stage. The QD-CV probes were introduced into cells, and the visible light excitation yielded photo-modulation nearly ten folds in intracellular environment. Exploiting the stochastic PL burst of QD-CVs and multiplexing capability of QDs, simultaneous multi-color super-resolution localizations were demonstrated. (4) Recent technological advances have expanded fluorescence imaging into the second near-infrared region (NIR-II; wavelength = 1000–1700 nm), providing high spatial resolution through deep tissues. However, bright and compact fluorophores are rare in this region, and sophisticated control over NIR-II probes has not been achieved yet. We showcase an enzyme-activatable NIR-II probe that exhibits turn-on fluorescence upon matrix metalloprotease activity in tumor microenvironment. 

 
Reference
1. (a) Y. Park et al, Advanced Functional Materials, 2018, 28, 1703450. (b) Y. Park, et al, ACS Nano, 2014, 8, 8896.
2. J. Park et al, ACS Nano, 2015, 6511.
3. S. Jung et al, Journal of the American Chemical Society, 2017, 139, 7603.
4. S. Jeong et al, Nano Letters, 2017, 17, 1378.
 

List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
63 [May 23. 2019] Molecular Engineering for Organic Electronics and Synchrotron X-rays Prof. Hyojung Kim (Pusan National University) Thu. 23 May. 2019
62 [May 16. 2019] Nano Structure Analysis by Synchrotron Small Angle X-ray Scattering Technique Dr. Hyungjoo-An (Pohang Accelerator Laboratory) Thu. 16 May. 2019
61 [May 9. 2019] Chemistry in Molecular Vessels file Prof. Partha Sarathi Mukherjee Thu. 9 May. 2019
60 [May 2. 2019] Theoretical studies of organic molecules in OLEDs: From chemical stability to the excited-state nature Prof. Dongwook-kim (Kyonggi University) Thu. 2 May. 2019
» [April 25. 2019] Colorful World of Quantum Dots Prof. Sungjee Kim (Pohang University of Science & Technology) Thu. 25 Apr. 2019
58 [April 4. 2019] Rational Design of Solid-State Materials with Asymmetric Coordination Environment Prof. Kang Min Ok (Sogang University) Thu. 4 Apr. 2019
57 [March 28. 2019] NMR Structural Studies of engineered novel antimicrobial peptides Prof. Yongae Kim (Hankuk University of Foreign Studies) Thu. 28 Mar. 2019
56 [March 21, 2019] Nanomaterials Design for Energy Conversion and Storage Prof. Jong-Hyuk Park (Yonsei University) Thu. 21 Mar. 2019
55 [March 27, 2019] Hyperpolarization Researches with NV center, 129Xe and Parahydrogen file Prof. Keunhong Jeong March 27, 2019
54 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
53 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
52 [March 5. 2019] Prof. Michael J. Sailor/Treatment of S. aureus Bacterial Infections with Porous Silicon Nanoparticles Prof. Michael J. Sailor (UC San Diego) Tuesday. 5 March. 2019
51 [Thu. 6 Dec. 2018] Prof. Dong-Ho Kim/Department of Chemistry, Yonsei University, Seoul, Korea Prof. Dong-Ho Kim (Yonsei University) Thu. 6 Dec. 2018
50 Fall semester 2018 Seminar Schedule file - -
49 [January 24, 2018] Electro-Optic Organic THz Wave Sources file Prof. O-Pil Kwon(Ajou University) January 24, 2018 (Wednesday)
48 [Thu. 30 Nov. 2017] Prof. Sunmin Ryu/Department of Chemistry, POSTECH, Pohang, South Korea Prof. Sunmin Ryu Thu. 30 Nov. 2017
47 [Thu. 23 Nov. 2017] Prof. Sung-Gon Kim/Department of Chemistry, Kyonggi University, Suwon, Korea Prof. Sung-Gon Kim Thu. 23 Nov. 2017
46 [November 14, 2017] Zero-Point Energy, Fluctuations, and Dissipation : A (Mostly) Quantum-Optical Perspective Prof. Milonni, Peter November 14, 2017
45 [Thu. 16 Nov. 2017] Prof. Hyungjun Kim/Department of Chemistry, and Graduate school of Energy, Environment, Water, and Sustainability (EEWS), KAIST, Daejeon, Korea Prof. Hyungjun Kim Thu. 16 Nov. 2017
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