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2019.04.22 11:21

[April 25. 2019] Colorful World of Quantum Dots

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Speaker Prof. Sungjee Kim (Pohang University of Science & Technology)
Date Thu. 25 Apr. 2019
Time 5:00pm
Venue #331, Asan Hall, College of Science

 Colorful World of Quantum Dots

 

 A few imaging applications using quantum dots (QDs) will be introduced, which will cover from visible to infrared(IR) for the wavelengths and from cellular super-resolution to whole body in vivo imaging for the object scale. (1) QDs were conjugated to tumor-specific antibodies(Abs) with zwitterionic surface coating to reduce nonspecific bindings. The Ab-QD probes were used to diagnose tumors for sectioned mouse tissues, fresh mouse colons stained ex vivo and in vivo, and also for fresh human colon adenoma tissues. The probes successfully detected not only cancers that are readily discernible by bare eyes but also hyperplasia and adenoma regions. Multiplexed QD, spray-and-wash, and endoscopy approach provided a significant advantage for detecting small or flat tumors that may be missed by conventional endoscopic examinations. QD-Ab probe was also used in conjunction with a ratiometric fluorescent molecular probe, cresyl violet–glutamic acid derivative, that ratiometrically switches between two fluorescent colors in response to the enzyme activity of λ-glutamyltranspeptidase. Co-application of the two kinds of probes, QD-Abs and the ratiometric molecular probe, afforded accurate visualization of carcinomas, hyperplasia and adenoma regions. (2) Amphiphilic polyethyleneimine derivatives (amPEIs) were synthesized and used to encapsulate dozens of QDs. The QD-amPEI showed very efficient QD cellular fluorescent labeling. Co-encapsulation of QDs and oxygen sensing phosphorescence Ru dyes allowed accurate and reversible oxygen sensing capability by the ratiometric signals, which was successfully applied to cellular and spheroid models. (3) Photo-modulating QDs were designed by conjugating crystal violets (CVs) on QD surface. The QD CV conjugates (QD-CVs) shows a single cycle of emission burst as go through the stage of initially quenched off to photo-activated on and back to photo-darkened off stage. The QD-CV probes were introduced into cells, and the visible light excitation yielded photo-modulation nearly ten folds in intracellular environment. Exploiting the stochastic PL burst of QD-CVs and multiplexing capability of QDs, simultaneous multi-color super-resolution localizations were demonstrated. (4) Recent technological advances have expanded fluorescence imaging into the second near-infrared region (NIR-II; wavelength = 1000–1700 nm), providing high spatial resolution through deep tissues. However, bright and compact fluorophores are rare in this region, and sophisticated control over NIR-II probes has not been achieved yet. We showcase an enzyme-activatable NIR-II probe that exhibits turn-on fluorescence upon matrix metalloprotease activity in tumor microenvironment. 

 
Reference
1. (a) Y. Park et al, Advanced Functional Materials, 2018, 28, 1703450. (b) Y. Park, et al, ACS Nano, 2014, 8, 8896.
2. J. Park et al, ACS Nano, 2015, 6511.
3. S. Jung et al, Journal of the American Chemical Society, 2017, 139, 7603.
4. S. Jeong et al, Nano Letters, 2017, 17, 1378.
 

List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
71 [Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst file Prof. James Y. Hamilton Wednesday 28 December 2016
70 [August 14. 2019] Principle of Semiconductor Quantum Cascade Laser and It’s Application to Chemical Gas Detection file Dr. Byeong-il Seo(Agency for Defense Development) Wed. 14 August. 2019
69 [March 5. 2019] Prof. Michael J. Sailor/Treatment of S. aureus Bacterial Infections with Porous Silicon Nanoparticles Prof. Michael J. Sailor (UC San Diego) Tuesday. 5 March. 2019
68 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
67 [October 15. 2019] A more sustainable chemistry with elemental sulfur file Dr. Thanh Binh Nguyen(Institut of Natural Product Chemistry) Tue. 15 October. 2019
66 [October 10, 2017] Novel Terahertz Spectroscopies file Director Mischa Bonn Tue, October 10, 2017
65 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
64 [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
63 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
62 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
61 [Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension Prof. Tae-Young Yoon Thursday 29 September 2016
60 [Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction Prof. Sung June Cho Thursday 26 May 2016
59 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
58 [Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy Prof. Chan Hyuk Kim Thursday 20 October 2016
57 [Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses Prof. Sunkyu Han Thursday 2 June 2016
56 [Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy Prof. Zhuang Liu Thursday 19 May 2016
55 [Thu. 17 Nov. 2016] Prof. Seunghoon Shin/Synthetic Methods Development based on Rational Analysis of Intermediates file Prof. Seunghoon Shin Thursday 17 November 2016
54 [Thu. 1 Dec. 2016] Prof. Sang-Yong Ju/Highly Pure Carbon Nanotubes sorted by a Flavin for Thin Film Transistor Applications Prof. Sang-Yong Ju Thursday 1 December 2016
53 [May 9. 2019] Chemistry in Molecular Vessels file Prof. Partha Sarathi Mukherjee Thu. 9 May. 2019
52 [Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea Prof. Woon Ju Song Thu. 9 Mar. 2017
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