Loading...
2016.09.20 16:02

[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions

?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
Extra Form
Speaker Prof. Jaeyoung Sung
Date Thursday 8 September 2016
Time 5:00pm
Venue #331, Asan Hall, College of Science

“Stochastic chemical dynamics in living cells and

its consequence for the control capacity of living cells

over biological functions”

 

 

To understand how and how accurately living cells control their biological functions, it is essential to construct a rigorous mathematical description for chemical dynamics of intracellular networks interacting with complex and hidden cell environment, which has been a formidable task. In this talk we introduce a novel model and stochastic kinetics for intracellular networks interacting with hidden cell environment, employing a complete description of cell state dynamics and its coupling to the system network. For a general model of intracellular birth-death processes, we present a simple and exact equation that relates the cell-to-cell variation in the product number to stochastic dynamics of birth and death processes occurring in cell environment. On the basis of the latter result, we propose an efficient method for quantitative analysis of the cell-to-cell variation in the mRNA and protein levels, which are responsible for phenotypic variations. Taking the new approach, we could provide excellent quantitative explanations for the control capacity of living cells over gene expression levels for a variety of different experimental systems in a unified manner. Our analysis of mRNA counting statistics in Escherichia coli shows that the transcription of an active gene is a strongly non-Poisson process whose rate has an oscillatory time correlation function. It has an important consequence for the cellular control over the transcriptional noise.

 

Refs: Lim et al., Phys. Rev. X 5, 031014 (2015); Yang et al., Nat. Commun. 5, 4761 (2014)

 

Prof. Jaeyoung Sung
Department of Chemistry & CRI-Center for Chemical Dynamics in Living Cells, Chung-Ang University, Seoul, Korea

 


  1. March 25th (Thu) Graduate Seminar / Prof. Yoo Jae-joong

    Professor Yoo Jae-joong (Sungkyunkwan University Department of Physics)
    Thursday, March 25, 2021
    Read More
  2. March 18th (Thu) Graduate Seminar / Professor Namjoong Kim

    Professor Namjoong Kim (Kyung Hee University Department of Pharmacy)
    Thursday, March 18, 2021
    Read More
  3. March 11th (Thu) Graduate Seminar / Professor Seongjun Moo

    Professor Seongjun Moo (Chosun University Military Department)
    Thursday, March 11, 2021
    Read More
  4. June 8, 2023 (Thursday) Professor Myungki Park

    Professor Myungki Park (Professor of Pukyong National University Department of Chemistry)
    Thursday, June 8, 2023
    Read More
  5. June 3rd (Thursday) Graduate Seminar / Professor Yuseong Chung

    Professor Yuseong Chung (KAIST Department of Biochemical Engineering)
    Thursday, June 3, 2021
    Read More
  6. June 16th (Thu) Graduate Seminar / Proffessor Philippe Guyot-Sionnest

    Proffessor Philippe Guyot-Sionnest (The University of Chicago)
    Thursday, June 16, 2022
    Read More
  7. June 1, 2023 (Thursday) Professor Go Min-seop

    Professor Koh Min-seop (Pusan ​​National University Department of Chemistry)
    Thursday, June 1, 2023
    Read More
  8. December 8th (Thu) Dr. Jieon Kwon (KIST)

    Dr. Kwon Ji-eon (Functional Composite Materials Research Center, Jeonbuk Institute of Advanced Composite Materials, Korea Institute of Science and Technology (KIST))
    Thursday, December 8, 2022
    Read More
  9. December 3rd (Thu) Graduate Seminar / Professor Seo Ji-Won

    Professor Seo Ji-Won (Gwangju Institute of Science and Technology Department of Chemistry)
    Thursday, December 3, 2020
    Read More
  10. December 2nd (Thu) Graduate Seminar / Prof. Haizheng Zhong

    Prof. Haizheng Zhong (School of Materials Science & Engineering, Beijing Institute of Technology)
    Thursday, December 2, 2021
    Read More
  11. December 15th (Thu) Professor Changhyeok Choi

    Professor Changhyeok Choi (POSTECH Department of Chemistry)
    Thursday, December 15, 2022
    Read More
  12. December 1st (Thu) Professor Park Yun-soo

    Professor Yunsoo Park (KAIST Department of Chemistry)
    Thursday, December 1, 2022
    Read More
  13. August 18th (Thu) Graduate School Special Seminar / Seongwon Kim Executive Director

    Seongwon Kim Executive Director (UDC Korea)
    Thursday, August 18, 2022
    Read More
  14. April 8th (Thu) Graduate Seminar / Professor Minsang Kwon

    Professor Minsang Kwon (Department of Materials Science and Engineering, Seoul National University)
    Thursday, April 8, 2021
    Read More
  15. April 7th (Thu) Graduate Seminar / Prof. Gerasimos Konstantatos

    Prof. Gerasimos Konstantatos (ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Spain)
    Thursday, April 7, 2022
    Read More
  16. April 6, 2023 (Thursday) Professor Hyungmin Kim

    Hyungmin Kim (Department of Applied Chemistry, Kookmin University)
    Thursday, April 6, 2023
    Read More
  17. April 6, 2023 (Thursday) Professor Hyungmin Kim

    Hyungmin Kim (Department of Applied Chemistry, Kookmin University)
    Thursday, April 6, 2023
    Read More
  18. April 21st (Thu) Graduate Seminar / Professor Kwon Oh-hoon

    Professor Kwon Oh-hoon (Ulsan National Institute of Science and Technology Department of Chemistry)
    Thursday, April 21, 2022
    Read More
  19. April 13, 2023 (Thu) Professor Baek Yoon-jeong

    Professor Yoonjung Baek (KAIST Department of Chemistry)
    Thursday, April 13, 2023
    Read More
  20. April 1st (Thu) Graduate Seminar / Prof. Seonwoo Lee

    Professor Seonwoo Lee (Chonnam National University Department of Chemistry)
    Thursday, April 1, 2021
    Read More
Board Pagination ‹ Prev 1 2 3 4 5 6 7 8 Next ›
/ 8

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Department of Chemistry, Korea University, Tel) +82-2-3290-3120
145 Anam-ro Seongbuk-gu Seoul, 02841, Republic of Korea
Copyright(c) 2014 KOREA UNIVERSITY DEPARTMENT of CHEMISTRY. All right reserved.