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2019.02.28 09:44

[March 5. 2019] Prof. Michael J. Sailor/Treatment of S. aureus Bacterial Infections with Porous Silicon Nanoparticles

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Speaker Prof. Michael J. Sailor (UC San Diego)
Date Tuesday. 5 March. 2019
Time 5:00pm
Venue #331. Asan Hall. College of Science

 

Treatment of S. aureus Bacterial

Infections with Porous Silicon

Nanoparticles

 

 The use of porous silicon nanoparticles for peptide-targeted delivery of therapeutic payloads and for luminescence imaging will be described. One area where there is clearly an unmet therapeutic need is in the treatment of antibiotic-resistant bacterial infections, and the deployment of porous silicon nanoparticles to meet this challenge will be described. Porous Si nanoparticles can be simultaneously loaded and sealed using aqueous solutions of the desired therapeutic (siRNA or small molecule antibiotics will be used as examples) in the presence of calcium or magnesium ions. The resulting nanostructures consist of drug loaded into the mesopores of the nanoparticle and sealed with biodegradable calcium or magnesium silicate. Attachment of functional peptides imparts targeting and cell penetration properties to the constructs that show improved gene silencing and therapeutic outcomes in vivo . The intrinsic photoluminescence that derives from quantum confinement in the silicon skeleton provides a built-in luminescent probe that can be used for in vivo and in vitro imaging and self-reporting drug delivery in these systems.


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
68 Fall semester 2016 Seminar Schedule file - -
67 Spring semester 2017 Seminar Schedule file - -
66 [Fri. 17 Mar. 2017] 9th RINS Symposium file - Fri. 17 Mar. 2017
65 [Thu. 27 Apr. 2017] Seminar was canceled! - -
64 [Wed. 5 July. 2017] Seminar is canceled! - -
63 7th Jilin-Korea-Waseda Alliance Annual Symposium file - August 17 ~ 19, 2017
62 Fall semester 2017 Seminar Schedule file - -
61 Fall semester 2018 Seminar Schedule file - -
60 [October 10, 2017] Novel Terahertz Spectroscopies file Director Mischa Bonn Tue, October 10, 2017
59 [August 14. 2019] Principle of Semiconductor Quantum Cascade Laser and It’s Application to Chemical Gas Detection file Dr. Byeong-il Seo(Agency for Defense Development) Wed. 14 August. 2019
58 [October 25, 2017] Ultrafast electron microscopy: applications in chemical and materials sciences Dr. Byung-Kuk Yoo October 25, 2017
57 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
56 [May 16. 2019] Nano Structure Analysis by Synchrotron Small Angle X-ray Scattering Technique Dr. Hyungjoo-An (Pohang Accelerator Laboratory) Thu. 16 May. 2019
55 [Fri. 13 Oct. 2017] Dr. J. Nathan Hohman/The Molecular Foundry, Lawrence Berkeley National Laboratory, California, USA Dr. J. Nathan Hohman Fri. 13 Oct. 2017
54 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
53 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
52 [October 15. 2019] A more sustainable chemistry with elemental sulfur file Dr. Thanh Binh Nguyen(Institut of Natural Product Chemistry) Tue. 15 October. 2019
51 [Thu. 13 Apr. 2017] Dr. Wan Ki Bae/Photoelectronic Hybrid Research Center, Korea Institute of Science and Technology, Seoul, Korea Dr. Wan Ki Bae Thu. 13 Apr. 2017
50 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
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