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2019.04.22 11:21

[April 25. 2019] Colorful World of Quantum Dots

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Speaker Prof. Sungjee Kim (Pohang University of Science & Technology)
Date Thu. 25 Apr. 2019
Time 5:00pm
Venue #331, Asan Hall, College of Science

 Colorful World of Quantum Dots

 

 A few imaging applications using quantum dots (QDs) will be introduced, which will cover from visible to infrared(IR) for the wavelengths and from cellular super-resolution to whole body in vivo imaging for the object scale. (1) QDs were conjugated to tumor-specific antibodies(Abs) with zwitterionic surface coating to reduce nonspecific bindings. The Ab-QD probes were used to diagnose tumors for sectioned mouse tissues, fresh mouse colons stained ex vivo and in vivo, and also for fresh human colon adenoma tissues. The probes successfully detected not only cancers that are readily discernible by bare eyes but also hyperplasia and adenoma regions. Multiplexed QD, spray-and-wash, and endoscopy approach provided a significant advantage for detecting small or flat tumors that may be missed by conventional endoscopic examinations. QD-Ab probe was also used in conjunction with a ratiometric fluorescent molecular probe, cresyl violet–glutamic acid derivative, that ratiometrically switches between two fluorescent colors in response to the enzyme activity of λ-glutamyltranspeptidase. Co-application of the two kinds of probes, QD-Abs and the ratiometric molecular probe, afforded accurate visualization of carcinomas, hyperplasia and adenoma regions. (2) Amphiphilic polyethyleneimine derivatives (amPEIs) were synthesized and used to encapsulate dozens of QDs. The QD-amPEI showed very efficient QD cellular fluorescent labeling. Co-encapsulation of QDs and oxygen sensing phosphorescence Ru dyes allowed accurate and reversible oxygen sensing capability by the ratiometric signals, which was successfully applied to cellular and spheroid models. (3) Photo-modulating QDs were designed by conjugating crystal violets (CVs) on QD surface. The QD CV conjugates (QD-CVs) shows a single cycle of emission burst as go through the stage of initially quenched off to photo-activated on and back to photo-darkened off stage. The QD-CV probes were introduced into cells, and the visible light excitation yielded photo-modulation nearly ten folds in intracellular environment. Exploiting the stochastic PL burst of QD-CVs and multiplexing capability of QDs, simultaneous multi-color super-resolution localizations were demonstrated. (4) Recent technological advances have expanded fluorescence imaging into the second near-infrared region (NIR-II; wavelength = 1000–1700 nm), providing high spatial resolution through deep tissues. However, bright and compact fluorophores are rare in this region, and sophisticated control over NIR-II probes has not been achieved yet. We showcase an enzyme-activatable NIR-II probe that exhibits turn-on fluorescence upon matrix metalloprotease activity in tumor microenvironment. 

 
Reference
1. (a) Y. Park et al, Advanced Functional Materials, 2018, 28, 1703450. (b) Y. Park, et al, ACS Nano, 2014, 8, 8896.
2. J. Park et al, ACS Nano, 2015, 6511.
3. S. Jung et al, Journal of the American Chemical Society, 2017, 139, 7603.
4. S. Jeong et al, Nano Letters, 2017, 17, 1378.
 

List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
68 Fall semester 2016 Seminar Schedule file - -
67 Spring semester 2017 Seminar Schedule file - -
66 [Fri. 17 Mar. 2017] 9th RINS Symposium file - Fri. 17 Mar. 2017
65 [Thu. 27 Apr. 2017] Seminar was canceled! - -
64 [Wed. 5 July. 2017] Seminar is canceled! - -
63 7th Jilin-Korea-Waseda Alliance Annual Symposium file - August 17 ~ 19, 2017
62 Fall semester 2017 Seminar Schedule file - -
61 Fall semester 2018 Seminar Schedule file - -
60 [October 10, 2017] Novel Terahertz Spectroscopies file Director Mischa Bonn Tue, October 10, 2017
59 [August 14. 2019] Principle of Semiconductor Quantum Cascade Laser and It’s Application to Chemical Gas Detection file Dr. Byeong-il Seo(Agency for Defense Development) Wed. 14 August. 2019
58 [October 25, 2017] Ultrafast electron microscopy: applications in chemical and materials sciences Dr. Byung-Kuk Yoo October 25, 2017
57 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
56 [May 16. 2019] Nano Structure Analysis by Synchrotron Small Angle X-ray Scattering Technique Dr. Hyungjoo-An (Pohang Accelerator Laboratory) Thu. 16 May. 2019
55 [Fri. 13 Oct. 2017] Dr. J. Nathan Hohman/The Molecular Foundry, Lawrence Berkeley National Laboratory, California, USA Dr. J. Nathan Hohman Fri. 13 Oct. 2017
54 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
53 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
52 [October 15. 2019] A more sustainable chemistry with elemental sulfur file Dr. Thanh Binh Nguyen(Institut of Natural Product Chemistry) Tue. 15 October. 2019
51 [Thu. 13 Apr. 2017] Dr. Wan Ki Bae/Photoelectronic Hybrid Research Center, Korea Institute of Science and Technology, Seoul, Korea Dr. Wan Ki Bae Thu. 13 Apr. 2017
50 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
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