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2017.03.31 11:35

[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea

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Speaker Prof. Woon Ju Song
Date Thu. 9 Mar. 2017
Time 5:00pm
Venue #331, Asan Hall, College of Science

 “Inorganic Chemistry in Proteinaceous Environments”

 

Natural enzymes exhibit high catalytic efficiency and selectivity for their dedicated chemical transformations, and the power of enzyme catalysis has enticed chemists to scrutinize and mimic the chemical mechanism and reactivities. Particularly, a third of natural enzymes are found with metal ions, suggesting that inorganic elements are crucial in biological environments. From the studies of a natural enzyme, toluene/o-xylene monooxygenase hydroxylase, which belongs to the family of carboxylatebridged diiron proteins, we demonstrated that the diiron active site generates a catalytically reactive intermediate during dioxygen activation, and the protein environment functions as a sophisticatedly programmed matrix that regulates overall catalytic process. Inspired by the beauty of biochemical architectures associated with metal ions, we have designed a protein that self-assembles into a tetramer via hydrophobic interactions, disulfide bonds, and zinc coordination. The artificial protein yields catalytically active zinc-binding sites, which has been further optimized for molecular interactions with a substrate, ampicillin, by directed evolution. We have learned that design of artificial metalloenzyme can be considered as a distinctive route of reproducing and developing orchestrated chemical/biological events, and we suppose that protein engineering can aid us to develop efficient and sustainable biocatalysts and biomaterials in conjunction with synthetic biology, bioinformatics, and other related fields.

 

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Prof. Woon Ju Song

Department of Chemistry, Seoul National University, Seoul, Korea


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
49 [Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea Prof. Won-jin Chung Thu. 8 Jun. 2017
48 [Thu. 6 Dec. 2018] Prof. Dong-Ho Kim/Department of Chemistry, Yonsei University, Seoul, Korea Prof. Dong-Ho Kim (Yonsei University) Thu. 6 Dec. 2018
47 [Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan Prof. Rong-Jie Chein Thu. 6 Apr. 2017
46 [April 4. 2019] Rational Design of Solid-State Materials with Asymmetric Coordination Environment Prof. Kang Min Ok (Sogang University) Thu. 4 Apr. 2019
45 [Thu. 30 Nov. 2017] Prof. Sunmin Ryu/Department of Chemistry, POSTECH, Pohang, South Korea Prof. Sunmin Ryu Thu. 30 Nov. 2017
44 [May 30. 2019] Palladium-Catalyzed Deprotonative Arylation of Azaarylmethyl Derivatives file Prof. Byeong-Seon Kim (Gyeongsang National University) Thu. 30 May. 2019
43 [Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea Prof. Jeong Ho Cho Thu. 30 Mar. 2017
42 [Thu. 28 Sep. 2017] Prof. Eunsung Lee/Department of Chemistry, POSTECH and Center for Self–assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea Prof. Eunsung Lee Thu. 28 Sep. 2017
41 [March 28. 2019] NMR Structural Studies of engineered novel antimicrobial peptides Prof. Yongae Kim (Hankuk University of Foreign Studies) Thu. 28 Mar. 2019
40 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
39 [Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul Prof. Wonsuk Kim Thu. 25 May. 2017
38 [April 25. 2019] Colorful World of Quantum Dots Prof. Sungjee Kim (Pohang University of Science & Technology) Thu. 25 Apr. 2019
37 [Thu. 23 Nov. 2017] Prof. Sung-Gon Kim/Department of Chemistry, Kyonggi University, Suwon, Korea Prof. Sung-Gon Kim Thu. 23 Nov. 2017
36 [May 23. 2019] Molecular Engineering for Organic Electronics and Synchrotron X-rays Prof. Hyojung Kim (Pusan National University) Thu. 23 May. 2019
35 [Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea Prof. Sangsu Bae Thu. 23 Mar. 2017
34 [March 21, 2019] Nanomaterials Design for Energy Conversion and Storage Prof. Jong-Hyuk Park (Yonsei University) Thu. 21 Mar. 2019
33 [May 2. 2019] Theoretical studies of organic molecules in OLEDs: From chemical stability to the excited-state nature Prof. Dongwook-kim (Kyonggi University) Thu. 2 May. 2019
32 [September 19. 2019] Monitoring photo-chemical reaction with Raman spectroscopy file Prof. Choi Han-Kyu (Kunsan National University) Thu. 19 September. 2019
31 [Thu. 18 May. 2017] Student Host Colloquium : 1,1-Bisborylalkane: New Class of Organoboron Compound for the Chemo, Regio and Stereoselective Organic Transformations Prof. Seung Hwan Cho Thu. 18 May. 2017
30 [Thu. 16 Nov. 2017] Prof. Hyungjun Kim/Department of Chemistry, and Graduate school of Energy, Environment, Water, and Sustainability (EEWS), KAIST, Daejeon, Korea Prof. Hyungjun Kim Thu. 16 Nov. 2017
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