Loading...
2017.03.31 11:35

[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea

?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
Extra Form
Speaker Prof. Woon Ju Song
Date Thu. 9 Mar. 2017
Time 5:00pm
Venue #331, Asan Hall, College of Science

 “Inorganic Chemistry in Proteinaceous Environments”

 

Natural enzymes exhibit high catalytic efficiency and selectivity for their dedicated chemical transformations, and the power of enzyme catalysis has enticed chemists to scrutinize and mimic the chemical mechanism and reactivities. Particularly, a third of natural enzymes are found with metal ions, suggesting that inorganic elements are crucial in biological environments. From the studies of a natural enzyme, toluene/o-xylene monooxygenase hydroxylase, which belongs to the family of carboxylatebridged diiron proteins, we demonstrated that the diiron active site generates a catalytically reactive intermediate during dioxygen activation, and the protein environment functions as a sophisticatedly programmed matrix that regulates overall catalytic process. Inspired by the beauty of biochemical architectures associated with metal ions, we have designed a protein that self-assembles into a tetramer via hydrophobic interactions, disulfide bonds, and zinc coordination. The artificial protein yields catalytically active zinc-binding sites, which has been further optimized for molecular interactions with a substrate, ampicillin, by directed evolution. We have learned that design of artificial metalloenzyme can be considered as a distinctive route of reproducing and developing orchestrated chemical/biological events, and we suppose that protein engineering can aid us to develop efficient and sustainable biocatalysts and biomaterials in conjunction with synthetic biology, bioinformatics, and other related fields.

 

1.JPG

 

 

Prof. Woon Ju Song

Department of Chemistry, Seoul National University, Seoul, Korea


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
29 [May 16. 2019] Nano Structure Analysis by Synchrotron Small Angle X-ray Scattering Technique Dr. Hyungjoo-An (Pohang Accelerator Laboratory) Thu. 16 May. 2019
28 [Thu. 14 Sep. 2017] Prof. Dokyoung Kim/Department of Anatomy and Neurobiology, Kyung Hee University, Seoul Prof. Dokyoung Kim Thu. 14 Sep. 2017
27 [Thu. 13 Apr. 2017] Dr. Wan Ki Bae/Photoelectronic Hybrid Research Center, Korea Institute of Science and Technology, Seoul, Korea Dr. Wan Ki Bae Thu. 13 Apr. 2017
26 [Thu. 12 Oct. 2017] Student Host Colloquium : Versatile Dendrimer-Encapsulated Nanoparticles for Analytical Applications Prof. Joohoon Kim Thu. 12 Oct. 2017
25 [Thu. 11 May. 2017] Prof. Andreas Heinrich/IBS Research, Center for Quantum Nanoscience, Seoul, South Korea Prof. Andreas Heinrich Thu. 11 May. 2017
24 [July 11. 2019] Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating Biological Environments in Vitro and in Vivo file Prof. Emily Que(The University of Texas at Austin) Thu. 11 July. 2019
23 [Thu. 1 Jun. 2017] Prof. Jong-Man Kim/Department of Chemical Engineering, Hanyang University, Seoul, Korea Prof. Jong-Man Kim Thu. 1 Jun. 2017
22 [October 31, 2017] New ways of vision: Protein structures in translational medicine and business development, my experience file Prof. Robert Huber(1988 Nobel Prize in Chemistry) October 31, 2017
21 [October 25, 2017] Ultrafast electron microscopy: applications in chemical and materials sciences Dr. Byung-Kuk Yoo October 25, 2017
20 [November 14, 2017] Zero-Point Energy, Fluctuations, and Dissipation : A (Mostly) Quantum-Optical Perspective Prof. Milonni, Peter November 14, 2017
19 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
18 [Mon. 9 Jan. 2017] Prof. Sungwook Woo/Wyss Institute for Biologically Inspired Engineering, Harvard University, USA Prof. Sungwook Woo Mon. 9 Jan. 2017
17 [Mon. 16 Oct. 2017] Prof. Kirk S. Schanze/Department of Chemistry, University of Texas at San Antonio, Texas, USA Prof. Kirk S. Schanze Mon. 16 Oct. 2017
16 [March 27, 2019] Hyperpolarization Researches with NV center, 129Xe and Parahydrogen file Prof. Keunhong Jeong March 27, 2019
15 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
14 [January 24, 2018] Electro-Optic Organic THz Wave Sources file Prof. O-Pil Kwon(Ajou University) January 24, 2018 (Wednesday)
13 [Fri. 17 Jun. 2016] Prof. Jianwei Sun/Remote Control in Brønsted Acid Catalysis: New Strategies for the Synthesis of Chiral Building Blocks and Medium Rings Prof. Jianwei Sun Friday 17 June 2016
12 [Fri. 30 Oct. 2017] Prof. Igor Rodin/Department of Chemistry, Moscow State University, Moscow, Russia Prof. Igor Rodin Fri. 30 Oct. 201
11 [Fri. 17 Mar. 2017] 9th RINS Symposium file - Fri. 17 Mar. 2017
10 [Fri. 16 Jun. 2017] Prof. Martin Thuo/Department of Materials Science and Engineering, Iowa State University, USA Prof. Martin Thuo Fri. 16 Jun. 2017
Board Pagination ‹ Prev 1 2 3 4 Next ›
/ 4

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Department of Chemistry, Korea University, Tel) +82-2-3290-3120
145 Anam-ro Seongbuk-gu Seoul, 02841, Republic of Korea
Copyright(c) 2014 KOREA UNIVERSITY DEPARTMENT of CHEMISTRY. All right reserved.