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2017.06.12 15:01

[Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea

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Speaker Prof. Won-jin Chung
Date Thu. 8 Jun. 2017
Time 5:00pm
Venue #633, Asan Hall, College of Science

“Part 1. A Catalytic Enantioselective Glycolate Aldol Reaction

via Lewis Base Activation of Lewis Acids”

 

Part 1. A general, efficient, Lewis-base catalyzed enantioselective addition of glycolate-derived silyl ketene acetals to a wide range of aldehydes will be presented. Both syn- and anti-diastereomers are accessible without changing the catalyst or controlling the geometry of the silyl ketene acetal. Simple modification of the size of alkyl groups on the silyl ketene acetal is sufficient to reverse the stereochemical course of the addition. The observed diastereoselectivity and reactivity could be rationalized by the analysis of six open transition state structures with the aid of computational analysis.

 

1.png

 

 

“Part 2. A General Enantioselective Approach to

the Chemical Synthesis of the Chlorosulfolipids”

 

Part 2. A concise and general approach has been developed for the enantioselective synthesis of three structurally related chlorosulfolipids. Key advances include highly stereocontrolled additions to a,b-dichloroaldehydes, kinetic resolution of complex chlorinated vinyl epoxide intermediates, and Z-selective alkene cross metathesis of cis-vinyl epoxides. This strategy facilitated the synthesis of enantioenriched danicalipin A, mytilipin A, and malhamensilipin A in nine, eight, and eleven steps, respectively.

 

2.png

 

 

 

 

References

1. Chung, W.-j.; Carlson, J. S.; Vanderwal, C. D. J. Org. Chem. 2014, 79, 2226–2241.

2. Chung, W.-j.; Vanderwal, C. D. Acc. Chem. Res. 2014, 47, 718–728.

3. Chung, W.-j.; Carlson, J. S.; Bedke, D. K.; Vanderwal, C. D. Angew. Chem. Int. Ed. 2013, 52, 10052–10055.

4. Denmark, S. E.; Chung, W.-j. J. Org. Chem. 2008, 73, 4582–4595.

5. Denmark, S. E.; Chung, W.-j. Angew. Chem. Int. Ed. 2008, 47, 1890–1892.

 

 

Prof. Won-jin Chung
Department of Chemistry, GIST, Gwangju, Republic of Korea


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