|Speaker||Prof. Byeong-Seon Kim (Gyeongsang National University)|
|Date||Thu. 30 May. 2019|
|Venue||#331, Asan Hall, College of Science|
Palladium-Catalyzed Deprotonative Arylation of Azaarylmethyl Derivatives
Aryl(azaaryl)methyl derivatives are prominent in biologically active small molecules, exhibiting antitumor, antivirus, anti-HIV, and antihistamine activities. In considering the synthesis of a family of drug-like molecules based on the aryl(pyridinyl)methane cores, we envisioned a united approach to access these important structural motifs based on a non-traditional umpolung approach. Our strategy entailed a palladium-catalyzed deprotonative cross-coupling process (DCCP) with pyridylmethyl ethers and aryl bromides by a noble Palladium-NIXANTPHOS catalyst to generate arylated secondary ethers, while the tertiary alcohols would be accessed via a tandem DCCP/[1,2]-Wittig rearrangement. The method has extended pertinent examples of such reactions with N-Boc benzylalkylamines, azaarylmethylamines, Isoindolinones, Benzoxazoles and diaryl(heteroaryl)methanes. A cheap nickel catalyst allows the less reactive but inexpensive aryl chlorides.
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