[July 11. 2019] Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating Biological Environments in Vitro and in Vivo

by webmaster posted Jul 02, 2019
?

Shortcut

PrevPrev Article

NextNext Article

ESCClose

+ - Up Down Comment Print
Extra Form
Speaker Prof. Emily Que(The University of Texas at Austin)
Date Thu. 11 July. 2019
Time 4:30pm
Venue #331, Asan Hall, College of Science

Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating

Biological Environments in Vitro and in Vivo

 

19F Magnetic resonance imaging (MRI) is an emerging technique for in vivo imaging, showing great promise due to the favorable NMR properties of the fluorine nucleus (high sensitivity, large ppm range) and the lack of detectable fluorine signal in biological systems. Imaging agents can be designed that exhibit either a turn-on or chemical shift response that is selective for a specific biological molecule or event. We are developing a series of metal complexes designed to report on different biological environments associated reductive stress (hypoxia), oxidative stress, changes in pH, metal ion concentration, and enzymatic activity. These sensors act via a switch from a paramagnetic to diamagnetic state upon reduction or oxidation at the metal center. Through careful tuning of the ligand scaffold, we have developed selective sensors for hypoxia and oxidative stress, showing promise for future applications for in vivo detection of these states in both cellular and animal disease models. New enhanced nanoparticle-based platforms based on metal-doped perfluorocarbons will also be discussed.

 

20190711_대학원특별세미나_Emily Que.pdf


Articles

1 2 3 4

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5