Loading...
2017.11.27 10:17

[Fri. 30 Oct. 2017] Prof. Igor Rodin/Department of Chemistry, Moscow State University, Moscow, Russia

?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
Extra Form
Speaker Prof. Igor Rodin
Date Fri. 30 Oct. 201
Time 5:00pm
Venue #331, Asan Hall, College of Science

“Unified strategy for HPLC-MS evaluation of

bioactive compounds in herbal products”

 

Safety, quality and composition evaluation of herbal products and food supplements based on botanical ingredients are of major concern, as they have usually not been through a pharmaceutical testing system as required for the approval of therapeutic phytopreparations. For screening of botanicals in herbal food supplements multi-targeted and group-targeted approaches may be applied. In both cases liquid chromatography coupled with a hybrid triple quadrupole linear ion trap mass spectrometry can be used. In the group-targeted approach botanicals are characterised by means of appropriate group of structurally related biomarkers instead of multi-targeted approach where the number of selected analytes is monitored based on multiple reaction monitoring survey. Therefore unified strategy for isolation, chromatographic separation and mass spectrometric detection and data handling should be employed for as many active compounds from herbal products as possible.

In this terms, isolation techniques for these compounds should be adopted for extraction of polar and less polar analytes, such as protodioscin and dioscin from T. terrestris, ginsenosides Rg1, Rb1, Re, Rb2 and Rg3, C-K, Rh2 from P. ginseng, salidroside and rosavin, rosarin from R. rosea etc. Therefore extraction parameters should be optimized for both polar and less polar biomarker compounds using single-factor or multi-factor experiments with different solvent systems. An efficient strategy for HPLC-MS group-targeted analysis of such extract was developed for comprehensive evaluation of chemical composition of plants intensively used for herbal product manufacturing. In this approach not only most studied biomarker compounds could be determined in single ion monitoring mode for characteristic group fragment ions but also their analogues and overall content. The sensitivity of this simple approach on the level of 10-50 ng/mL is higher than of existing HPLC-UV quality control methods which are not convenient for several groups of herbal constituents such as steroids and triterpenoids.

This work was supported by Russian Science Foundation (Grant No. 17-13-01146) for Moscow State University.


List of Articles
No. Subject Speaker Date
Notice Fall semester 2018 Seminar Schedule file - -
51 [Wed. 5 July. 2017] Seminar is canceled! - -
50 [Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst file Prof. James Y. Hamilton Wednesday 28 December 2016
49 [Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea Prof. Woon Ju Song Thu. 9 Mar. 2017
48 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
47 [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
46 [Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea Prof. Won-jin Chung Thu. 8 Jun. 2017
45 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
44 [Thu. 6 Dec. 2018] Prof. Dong-Ho Kim/Department of Chemistry, Yonsei University, Seoul, Korea Prof. Dong-Ho Kim (Yonsei University) Thu. 6 Dec. 2018
43 [Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan Prof. Rong-Jie Chein Thu. 6 Apr. 2017
42 [Thu. 30 Nov. 2017] Prof. Sunmin Ryu/Department of Chemistry, POSTECH, Pohang, South Korea Prof. Sunmin Ryu Thu. 30 Nov. 2017
41 [Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea Prof. Jeong Ho Cho Thu. 30 Mar. 2017
40 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
39 [Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension Prof. Tae-Young Yoon Thursday 29 September 2016
38 [Thu. 28 Sep. 2017] Prof. Eunsung Lee/Department of Chemistry, POSTECH and Center for Self–assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea Prof. Eunsung Lee Thu. 28 Sep. 2017
37 [Thu. 27 Apr. 2017] Seminar was canceled! - -
36 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
35 [Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction Prof. Sung June Cho Thursday 26 May 2016
34 [Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul Prof. Wonsuk Kim Thu. 25 May. 2017
33 [Thu. 23 Nov. 2017] Prof. Sung-Gon Kim/Department of Chemistry, Kyonggi University, Suwon, Korea Prof. Sung-Gon Kim Thu. 23 Nov. 2017
32 [Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea Prof. Sangsu Bae Thu. 23 Mar. 2017
Board Pagination ‹ Prev 1 2 3 Next ›
/ 3

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Department of Chemistry, Korea University, Tel) +82-2-3290-3120
145 Anam-ro Seongbuk-gu Seoul, 02841, Republic of Korea
Copyright(c) 2014 KOREA UNIVERSITY DEPARTMENT of CHEMISTRY. All right reserved.