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2016.07.29 15:26

[Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy

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Speaker Prof. Zhuang Liu
Date Thursday 19 May 2016
Time 5:00pm
Venue #331, Asan Hall, College of Science

Nanotechnology for enhanced cancer radiation therapy 

and immunotherapy

 

Nanomaterials especially functional inorganic nanomaterials exhibit a range of unique inherent physical and chemical properties useful in biomedicine. Starting from 2009, our group has been working on the development of functional nanomaterials including carbon nanomaterials, rare earth upconversion nanoparticles (UCNPs), metal oxide and sulfide nanostructures, organic nanoparticles as well as natural biomaterials, for applications in multimodal biomedical imaging, drug delivery, as well as photo-therapies of cancer. In the first part of this talk, I will introduce our latest efforts on the development of nanotechnology to enhance the efficacy of cancer radiation therapy (RT), one of three mainstream cancer treatment methods used in the clinic. We have uncovered that certain types of inorganic nanomaterials could absorb X-ray, and thereby concentrate a great deal of ionization energy locally in the tumor to enhance the efficacy of RT. With the help of nanotechnology, we could also change the tumor microenvironment (e.g. tumor hypoxia) to overcome hypoxia-associated RT resistance by tumors. In the second part of this talk, I will then discuss our recent studies in the area of nano-immunotherapy. We have tried to combine photothermal therapy with immunotherapy using nano-agents which not only exhibit strong near-infrared (NIR) absorbance for efficient photothermal conversion, but also serve as nano-adjuvants to promote the immunological responses. Stimulated by the tumor-associated antigens released after photothermal tumor ablation, the triggered immunological responses if in combination with anti-CTLA4 therapy to suppress the activity of regulatory T cells could result in effective inhibition of tumor cells remaining in the body, promising for treatment of cancer metastasis.


Prof. Zhuang Liu
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM),
Soochow University, China


List of Articles
No. Subject Speaker Date
Notice Spring semester 2017 Seminar Schedule file - -
13 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
12 [Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy Prof. Chan Hyuk Kim Thursday 20 October 2016
11 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
10 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
9 [Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension Prof. Tae-Young Yoon Thursday 29 September 2016
8 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
7 [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
6 Fall semester 2016 Seminar Schedule file - -
5 [Fri. 17 Jun. 2016] Prof. Jianwei Sun/Remote Control in Brønsted Acid Catalysis: New Strategies for the Synthesis of Chiral Building Blocks and Medium Rings Prof. Jianwei Sun Friday 17 June 2016
4 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
3 [Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses Prof. Sunkyu Han Thursday 2 June 2016
2 [Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction Prof. Sung June Cho Thursday 26 May 2016
» [Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy Prof. Zhuang Liu Thursday 19 May 2016
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