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2016.07.29 15:43

[Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses

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Speaker Prof. Sunkyu Han
Date Thursday 2 June 2016
Time 5:00pm
Venue #331, Asan Hall, College of Science

Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses

 

One of the major goals of synthetic organic chemists is a controlled and rapid generation of complex molecules with high functional impact. Natural products, secondary metabolites produced by living organisms, can serve as outstanding platforms to achieve this goal. Structural complexity of natural products can spark the development of novel synthetic approaches and their biological activity can boost the discovery of new therapeutics.
Biological systems have developed enzymes for the formation of bonds that can streamline the assembly of secondary metabolites. We are interested in identifying those key bonds and developing chemical tools for the formation of those bonds, which would result in efficient total syntheses. Herein, I present the total syntheses of agelastatins,1 trigonoliimines2 and oxa-azaspirononedione containing natural products as examples of the biosynthetic hypotheses-guided synthetic approaches.

 

References

1. Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. “Synthesis and Anticancer Activity of all Known (–)-Agelastatin Alkaloids.” J. Org. Chem. 2013, 78, 11970.

2. Han, S.; Morrison, K.; Hergenrother, P. J.; Movassaghi, M. “Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines.” J. Org. Chem. 2014, 79, 473. 

 

 

Prof. Sunkyu Han
Department of Chemistry, KAIST, Republic of Korea

 


List of Articles
No. Subject Speaker Date
Notice Fall semester 2017 Seminar Schedule file - -
23 [Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan Prof. Rong-Jie Chein Thu. 6 Apr. 2017
22 [Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea Prof. Jeong Ho Cho Thu. 30 Mar. 2017
21 [Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea Prof. Sangsu Bae Thu. 23 Mar. 2017
20 [Fri. 17 Mar. 2017] 9th RINS Symposium file - Fri. 17 Mar. 2017
19 [Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea Prof. Woon Ju Song Thu. 9 Mar. 2017
18 Spring semester 2017 Seminar Schedule file - -
17 [Mon. 9 Jan. 2017] Prof. Sungwook Woo/Wyss Institute for Biologically Inspired Engineering, Harvard University, USA Prof. Sungwook Woo Mon. 9 Jan. 2017
16 [Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst file Prof. James Y. Hamilton Wednesday 28 December 2016
15 [Thu. 1 Dec. 2016] Prof. Sang-Yong Ju/Highly Pure Carbon Nanotubes sorted by a Flavin for Thin Film Transistor Applications Prof. Sang-Yong Ju Thursday 1 December 2016
14 [Thu. 17 Nov. 2016] Prof. Seunghoon Shin/Synthetic Methods Development based on Rational Analysis of Intermediates file Prof. Seunghoon Shin Thursday 17 November 2016
13 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
12 [Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy Prof. Chan Hyuk Kim Thursday 20 October 2016
11 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
10 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
9 [Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension Prof. Tae-Young Yoon Thursday 29 September 2016
8 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
7 [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
6 Fall semester 2016 Seminar Schedule file - -
5 [Fri. 17 Jun. 2016] Prof. Jianwei Sun/Remote Control in Brønsted Acid Catalysis: New Strategies for the Synthesis of Chiral Building Blocks and Medium Rings Prof. Jianwei Sun Friday 17 June 2016
4 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
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