|Speaker||Prof. Sunkyu Han|
|Date||Thursday 2 June 2016|
|Venue||#331, Asan Hall, College of Science|
Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses
One of the major goals of synthetic organic chemists is a controlled and rapid generation of complex molecules with high functional impact. Natural products, secondary metabolites produced by living organisms, can serve as outstanding platforms to achieve this goal. Structural complexity of natural products can spark the development of novel synthetic approaches and their biological activity can boost the discovery of new therapeutics.
Biological systems have developed enzymes for the formation of bonds that can streamline the assembly of secondary metabolites. We are interested in identifying those key bonds and developing chemical tools for the formation of those bonds, which would result in efficient total syntheses. Herein, I present the total syntheses of agelastatins,1 trigonoliimines2 and oxa-azaspirononedione containing natural products as examples of the biosynthetic hypotheses-guided synthetic approaches.
1. Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. “Synthesis and Anticancer Activity of all Known (–)-Agelastatin Alkaloids.” J. Org. Chem. 2013, 78, 11970.
2. Han, S.; Morrison, K.; Hergenrother, P. J.; Movassaghi, M. “Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines.” J. Org. Chem. 2014, 79, 473.
Prof. Sunkyu Han
Department of Chemistry, KAIST, Republic of Korea
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|Notice||Spring semester 2017 Seminar Schedule||-||-|
|13||[Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery||Prof. Min-Sik Kim||Thursday 3 November 2016|
|12||[Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy||Prof. Chan Hyuk Kim||Thursday 20 October 2016|
|11||[Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis||Prof. Amir H. Hoveyda||Monday 13 October 2016|
|10||[Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons||Prof. Young S. Park||Thursday 6 October 2016|
|9||[Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension||Prof. Tae-Young Yoon||Thursday 29 September 2016|
|8||[Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions||Prof. Anna Lee||Thursday 22 September 2016|
|7||[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions||Prof. Jaeyoung Sung||Thursday 8 September 2016|
|6||Fall semester 2016 Seminar Schedule||-||-|
|5||[Fri. 17 Jun. 2016] Prof. Jianwei Sun/Remote Control in Brønsted Acid Catalysis: New Strategies for the Synthesis of Chiral Building Blocks and Medium Rings||Prof. Jianwei Sun||Friday 17 June 2016|
|4||[Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits||Prof. Yong-Young Noh||Thursday 9 June 2016|
|»||[Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses||Prof. Sunkyu Han||Thursday 2 June 2016|
|2||[Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction||Prof. Sung June Cho||Thursday 26 May 2016|
|1||[Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy||Prof. Zhuang Liu||Thursday 19 May 2016|
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