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2016.09.20 16:02

[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions

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Speaker Prof. Jaeyoung Sung
Date Thursday 8 September 2016
Time 5:00pm
Venue #331, Asan Hall, College of Science

“Stochastic chemical dynamics in living cells and

its consequence for the control capacity of living cells

over biological functions”

 

 

To understand how and how accurately living cells control their biological functions, it is essential to construct a rigorous mathematical description for chemical dynamics of intracellular networks interacting with complex and hidden cell environment, which has been a formidable task. In this talk we introduce a novel model and stochastic kinetics for intracellular networks interacting with hidden cell environment, employing a complete description of cell state dynamics and its coupling to the system network. For a general model of intracellular birth-death processes, we present a simple and exact equation that relates the cell-to-cell variation in the product number to stochastic dynamics of birth and death processes occurring in cell environment. On the basis of the latter result, we propose an efficient method for quantitative analysis of the cell-to-cell variation in the mRNA and protein levels, which are responsible for phenotypic variations. Taking the new approach, we could provide excellent quantitative explanations for the control capacity of living cells over gene expression levels for a variety of different experimental systems in a unified manner. Our analysis of mRNA counting statistics in Escherichia coli shows that the transcription of an active gene is a strongly non-Poisson process whose rate has an oscillatory time correlation function. It has an important consequence for the cellular control over the transcriptional noise.

 

Refs: Lim et al., Phys. Rev. X 5, 031014 (2015); Yang et al., Nat. Commun. 5, 4761 (2014)

 

Prof. Jaeyoung Sung
Department of Chemistry & CRI-Center for Chemical Dynamics in Living Cells, Chung-Ang University, Seoul, Korea

 


List of Articles
No. Subject Speaker Date
Notice Spring semester 2017 Seminar Schedule file - -
13 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
12 [Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy Prof. Chan Hyuk Kim Thursday 20 October 2016
11 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
10 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
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8 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
» [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
6 Fall semester 2016 Seminar Schedule file - -
5 [Fri. 17 Jun. 2016] Prof. Jianwei Sun/Remote Control in Brønsted Acid Catalysis: New Strategies for the Synthesis of Chiral Building Blocks and Medium Rings Prof. Jianwei Sun Friday 17 June 2016
4 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
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2 [Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction Prof. Sung June Cho Thursday 26 May 2016
1 [Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy Prof. Zhuang Liu Thursday 19 May 2016
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