Loading...
2016.09.20 16:02

[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions

?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
?

Shortcut

PrevPrev Article

NextNext Article

+ - Up Down Comment Print
Extra Form
Speaker Prof. Jaeyoung Sung
Date Thursday 8 September 2016
Time 5:00pm
Venue #331, Asan Hall, College of Science

“Stochastic chemical dynamics in living cells and

its consequence for the control capacity of living cells

over biological functions”

 

 

To understand how and how accurately living cells control their biological functions, it is essential to construct a rigorous mathematical description for chemical dynamics of intracellular networks interacting with complex and hidden cell environment, which has been a formidable task. In this talk we introduce a novel model and stochastic kinetics for intracellular networks interacting with hidden cell environment, employing a complete description of cell state dynamics and its coupling to the system network. For a general model of intracellular birth-death processes, we present a simple and exact equation that relates the cell-to-cell variation in the product number to stochastic dynamics of birth and death processes occurring in cell environment. On the basis of the latter result, we propose an efficient method for quantitative analysis of the cell-to-cell variation in the mRNA and protein levels, which are responsible for phenotypic variations. Taking the new approach, we could provide excellent quantitative explanations for the control capacity of living cells over gene expression levels for a variety of different experimental systems in a unified manner. Our analysis of mRNA counting statistics in Escherichia coli shows that the transcription of an active gene is a strongly non-Poisson process whose rate has an oscillatory time correlation function. It has an important consequence for the cellular control over the transcriptional noise.

 

Refs: Lim et al., Phys. Rev. X 5, 031014 (2015); Yang et al., Nat. Commun. 5, 4761 (2014)

 

Prof. Jaeyoung Sung
Department of Chemistry & CRI-Center for Chemical Dynamics in Living Cells, Chung-Ang University, Seoul, Korea

 


  1. November 10th (Thu) Professor Bongsoo Kim

    Professor Bongsoo Kim (Ulsan National Institute of Science and Technology Department of Chemistry)
    Thursday, November 10, 2022
    Read More
  2. 2022 International Symposium on Bioactive and Bioengineering Materials

    BK21 Chemistry Education Research Center
    November 22, 2022 (Tuesday)
    Read More
  3. November 3rd (Thu) Professor Yunhak Kim

    Professor Yunhak Kim (Busan ​​National University School of Medicine)
    Thursday, November 3, 2022
    Read More
  4. October 28th (Fri) Joonho Kim, Research Director (Merck)

    Joonho Kim, Research Director (Merck)
    October 28, 2022 (Fri)
    Read More
  5. October 17th (Mon) Dr. Keum Kyo-chang

    Dr. Keum Kyo-chang (Brain Medicine Research Center, Korea Institute of Science and Technology)
    Monday, October 17, 2022
    Read More
  6. October 13 (Thu) Professor Han Seung-woo

    Professor Seungwoo Han (Department of Materials Science and Engineering, Seoul National University)
    Thursday, October 13, 2022
    Read More
  7. 10/6 (Thu) Professor Choi Myeong-ryong

    Professor Myungryong Cho (Gyeongsang National University Department of Chemistry)
    Thursday, September 29, 2022
    Read More
  8. 9/29 (Thu) Professor Pilho Lee

    Professor Pilho Lee (Kangwon National University Department of Chemistry)
    Thursday, September 29, 2022
    Read More
  9. September 22nd (Thu) Graduate Seminar / Professor Heejae Kim

    Professor Heejae Kim (POSTECH Department of Physics)
    Thursday, September 22, 2022
    Read More
  10. September 23rd (Fri) Graduate School Special Seminar / Lee Nam-yang Expert

    Lee Nam-yang Expert (Idemitsu Electronic Materials Korea Co., Ltd.)
    Friday, September 23, 2022
    Read More
  11. August 18th (Thu) Graduate School Special Seminar / Seongwon Kim Executive Director

    Seongwon Kim Executive Director (UDC Korea)
    Thursday, August 18, 2022
    Read More
  12. June 16th (Thu) Graduate Seminar / Proffessor Philippe Guyot-Sionnest

    Proffessor Philippe Guyot-Sionnest (The University of Chicago)
    Thursday, June 16, 2022
    Read More
  13. June 10th (Fri) Graduate Seminar / Bing Zhang, Ph.D.

    Bing Zhang, Ph.D. (Baylor College of Medicine)
    Fri, Jun 10, 2022
    Read More
  14. May 26th (Thursday) Graduate Seminar / Professor Yunjeong Hwang

    Professor Yunjeong Hwang (Department of Chemistry, Seoul National University)
    Thursday, May 26, 2022
    Read More
  15. May 19th (Thu) Graduate Seminar / Professor Dongmyung Shin

    Professor Dongmyung Shin (Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong)
    Thursday, May 19, 2022
    Read More
  16. April 29 (Fri) Graduate Seminar / Luther Beegle, PhD

    Luther Beegle, PhD (Principle Investigator of Perseverance Rover SHEROLC instrument, Mars 2020 mission NASA-Jet Propulsion Laboratory, California Institute of Technology)
    April 29, 2022 (Fri)
    Read More
  17. April 21st (Thu) Graduate Seminar / Professor Kwon Oh-hoon

    Professor Kwon Oh-hoon (Ulsan National Institute of Science and Technology Department of Chemistry)
    Thursday, April 21, 2022
    Read More
  18. April 7th (Thu) Graduate Seminar / Prof. Gerasimos Konstantatos

    Prof. Gerasimos Konstantatos (ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Spain)
    Thursday, April 7, 2022
    Read More
  19. March 31st (Thu) Graduate Seminar / Professor Lim Dae-woon

    Professor Lim Dae-woon (Department of Chemistry and Medicine, Yonsei University)
    Thursday, March 31, 2022
    Read More
  20. January 4th (Tuesday) Special Seminar / Dr. Tae Soo Choi

    Dr. Tae Soo Choi (University of California, San Diego (UCSD), Department of Chemistry and Biochemistry)
    Tuesday, January 4, 2022
    Read More
Board Pagination ‹ Prev 1 2 3 4 5 6 7 8 Next ›
/ 8

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 Cancel

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Department of Chemistry, Korea University, Tel) +82-2-3290-3120
145 Anam-ro Seongbuk-gu Seoul, 02841, Republic of Korea
Copyright(c) 2014 KOREA UNIVERSITY DEPARTMENT of CHEMISTRY. All right reserved.