|Speaker||Prof. Sunkyu Han|
|Date||Thursday 2 June 2016|
|Venue||#331, Asan Hall, College of Science|
Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses
One of the major goals of synthetic organic chemists is a controlled and rapid generation of complex molecules with high functional impact. Natural products, secondary metabolites produced by living organisms, can serve as outstanding platforms to achieve this goal. Structural complexity of natural products can spark the development of novel synthetic approaches and their biological activity can boost the discovery of new therapeutics.
Biological systems have developed enzymes for the formation of bonds that can streamline the assembly of secondary metabolites. We are interested in identifying those key bonds and developing chemical tools for the formation of those bonds, which would result in efficient total syntheses. Herein, I present the total syntheses of agelastatins,1 trigonoliimines2 and oxa-azaspirononedione containing natural products as examples of the biosynthetic hypotheses-guided synthetic approaches.
1. Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. “Synthesis and Anticancer Activity of all Known (–)-Agelastatin Alkaloids.” J. Org. Chem. 2013, 78, 11970.
2. Han, S.; Morrison, K.; Hergenrother, P. J.; Movassaghi, M. “Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines.” J. Org. Chem. 2014, 79, 473.
Prof. Sunkyu Han
Department of Chemistry, KAIST, Republic of Korea
|Notice||Fall semester 2017 Seminar Schedule||-||-|
|43||[Wed. 5 July. 2017] Seminar is canceled!||-||-|
|42||[Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst||Prof. James Y. Hamilton||Wednesday 28 December 2016|
|41||[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea||Prof. Woon Ju Song||Thu. 9 Mar. 2017|
|40||[Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits||Prof. Yong-Young Noh||Thursday 9 June 2016|
|39||[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions||Prof. Jaeyoung Sung||Thursday 8 September 2016|
|38||[Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea||Prof. Won-jin Chung||Thu. 8 Jun. 2017|
|37||[Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons||Prof. Young S. Park||Thursday 6 October 2016|
|36||[Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan||Prof. Rong-Jie Chein||Thu. 6 Apr. 2017|
|35||[Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea||Prof. Jeong Ho Cho||Thu. 30 Mar. 2017|
|34||[Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery||Prof. Min-Sik Kim||Thursday 3 November 2016|
|33||[Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension||Prof. Tae-Young Yoon||Thursday 29 September 2016|
|32||[Thu. 28 Sep. 2017] Prof. Eunsung Lee/Department of Chemistry, POSTECH and Center for Self–assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea||Prof. Eunsung Lee||Thu. 28 Sep. 2017|
|31||[Thu. 27 Apr. 2017] Seminar was canceled!||-||-|
|30||[Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea||Dr. Jung-Nyoung Heo||Thu. 26 Oct. 2017|
|29||[Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction||Prof. Sung June Cho||Thursday 26 May 2016|
|28||[Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul||Prof. Wonsuk Kim||Thu. 25 May. 2017|
|27||[Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea||Prof. Sangsu Bae||Thu. 23 Mar. 2017|
|26||[Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions||Prof. Anna Lee||Thursday 22 September 2016|
|25||[Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy||Prof. Chan Hyuk Kim||Thursday 20 October 2016|
|»||[Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses||Prof. Sunkyu Han||Thursday 2 June 2016|
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