|Speaker||Prof. Anna Lee|
|Date||Thursday 22 September 2016|
|Venue||#331, Asan Hall, College of Science|
Organocatalyzed Asymmetric Reactions
The Catalytic Asymmetric Knoevenagel Condensation: The Knoevenagel condensation reaction developed by Emil Knoevenagel in 1896 is a powerful and efficient carbon-carbon bond forming reaction, but also the root of aminocatalysis. Remarkably though, while the Knoevenagel reaction, as the historic basis of all aminocatalyzed processes, has been incorporated into asymmetric organocascades and domino reactions, and even chiral auxiliary derived malonates have been studied, a variation in which the Knoevenagel reaction itself is utilized to establish asymmetry remained elusive. The main problems of the reaction were reactivity and stereoselectivity issues as well as the formation of by-products. The goal of this work was to develop the first enantioselective Knoevenagel condensation reaction using a novel chiral amine catalyst based on a dynamic kinetic resolution (DKR). Various chiral amine catalysts were synthesized, and we found that modified cinchona based amine catalysts provided the desired product in high yield and enantioselectivity.
A Cooperative N-Heterocyclic Carbene/Chiral phosphate Catalysis System for Allenolate Annulations: NHC-catalyzed homoenolate additions to various electrophiles represent an enabling class of transformations that have been employed for the construction of complex hetero- and carbocyclic system through unconventional Umpolung reactivity. Recently, our group developed Lewis acid/NHC cooperative catalysis to develope novel transformations. In this study, we have extended the scope of cooperative catalysis by employing chiral phosphoric acids for the first time and this novel cooperative catalysis was applied to the challenging allenolate annulation reaction (Figure 1). A limited number of reports of NHC-catalyzed homoenolate additions involving alkynyl aldehydes have appeared. We have developed a highly efficient asymmetric [3+2] annulation reaction of alkynyl aldehydes withα-ketoesters via NHC/chiral phosphate cooperative catalysis.
1. Lee, A.; Michrowska, A.; S.-Mosse, S.; List, B., Angew. Chem. Int. Ed. 2011, 50, 1707.
2. Lee, A.; Reisinger, C.; List, B., Adv. Synth. Catal. 2012, 354, 1701.
3. Lee, A.; Scheidt, K. A., Angew. Chem. Int. Ed. 2014, 53, 7594.
4. Lee, A.; Younai, A. ; Price, C. K. ; Izquierdo, J. ; Mishra, R. K. ; Scheidt, K. A., J. Am. Chem. Soc. 2014,136, 10589.
5. Lee, A.; Scheidt, K. A., Chem. Commun. 2015, 51, 3407.
Prof. Anna Lee
Myongji University, Department of Chemistry, Yongin, Korea
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|Notice||Fall semester 2017 Seminar Schedule||-||-|
|43||[Wed. 5 July. 2017] Seminar is canceled!||-||-|
|42||[Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst||Prof. James Y. Hamilton||Wednesday 28 December 2016|
|41||[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea||Prof. Woon Ju Song||Thu. 9 Mar. 2017|
|40||[Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits||Prof. Yong-Young Noh||Thursday 9 June 2016|
|39||[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions||Prof. Jaeyoung Sung||Thursday 8 September 2016|
|38||[Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea||Prof. Won-jin Chung||Thu. 8 Jun. 2017|
|37||[Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons||Prof. Young S. Park||Thursday 6 October 2016|
|36||[Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan||Prof. Rong-Jie Chein||Thu. 6 Apr. 2017|
|35||[Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea||Prof. Jeong Ho Cho||Thu. 30 Mar. 2017|
|34||[Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery||Prof. Min-Sik Kim||Thursday 3 November 2016|
|33||[Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension||Prof. Tae-Young Yoon||Thursday 29 September 2016|
|32||[Thu. 28 Sep. 2017] Prof. Eunsung Lee/Department of Chemistry, POSTECH and Center for Self–assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea||Prof. Eunsung Lee||Thu. 28 Sep. 2017|
|31||[Thu. 27 Apr. 2017] Seminar was canceled!||-||-|
|30||[Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea||Dr. Jung-Nyoung Heo||Thu. 26 Oct. 2017|
|29||[Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction||Prof. Sung June Cho||Thursday 26 May 2016|
|28||[Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul||Prof. Wonsuk Kim||Thu. 25 May. 2017|
|27||[Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea||Prof. Sangsu Bae||Thu. 23 Mar. 2017|
|»||[Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions||Prof. Anna Lee||Thursday 22 September 2016|
|25||[Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy||Prof. Chan Hyuk Kim||Thursday 20 October 2016|
|24||[Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses||Prof. Sunkyu Han||Thursday 2 June 2016|
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