Proteogenomic Characterization of Human Early-Onset Gastric Cancer

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author Sang-Won Lee
Homepage http://ionchem.korea.ac.kr/
journal Cancer Cell 35, 111–124 January 14, 2019
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Dong-Gi Mun(제1저자, 박사과정)

 

 We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.

 

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https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30574-9


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