|journal||Cancer Cell 35, 111–124 January 14, 2019|
Dong-Gi Mun(제1저자, 박사과정)
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
« Prev Harnessing Intramolecular Rotation to Enhance Two‐photon Imag...Harnessing Intramolecular Rotation to Enhance Two‐photon Imag... 2019.03.18by webmaster 〈
Chemiluminescent Probe for the In Vitro and In Vivo Imaging o... Next »Chemiluminescent Probe for the In Vitro and In Vivo Imaging o... 2019.01.11by webmaster 〉
Designed by sketchbooks.co.kr / sketchbook5 board skin