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Mechanical Force for the Transformation of Aziridine into Imine
| author | Hyo Jae Yoon |
|---|---|
| Homepage | https://hyojaeyoon.wixsite.com/omml |
| journal | Angewandte Chemie |
Force-selective mechanochemical reactions may be important for applications in polymer mechanochemistry, yet it is difficult to achieve such reactions. This paper reports that cis-N-phthalimidoaziridine incorporated into a macromolecular backbone undergoes migration of N-phthalimido group to afford imine under mechanochemical condition and not thermal one. The imine is further hydrolyzed by water bifurcating into amine and aldehyde. These structural transformations are confirmed by 1H NMR and FT-IR spectroscopic analyses. Computational simulations are conducted for the aziridine mechanophore to propose the mechanism of reaction and define the substrate scope of reaction.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202109358
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