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2019.07.02 10:43

[July 11. 2019] Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating Biological Environments in Vitro and in Vivo

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Speaker Prof. Emily Que(The University of Texas at Austin)
Date Thu. 11 July. 2019
Time 4:30pm
Venue #331, Asan Hall, College of Science

Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating

Biological Environments in Vitro and in Vivo

 

19F Magnetic resonance imaging (MRI) is an emerging technique for in vivo imaging, showing great promise due to the favorable NMR properties of the fluorine nucleus (high sensitivity, large ppm range) and the lack of detectable fluorine signal in biological systems. Imaging agents can be designed that exhibit either a turn-on or chemical shift response that is selective for a specific biological molecule or event. We are developing a series of metal complexes designed to report on different biological environments associated reductive stress (hypoxia), oxidative stress, changes in pH, metal ion concentration, and enzymatic activity. These sensors act via a switch from a paramagnetic to diamagnetic state upon reduction or oxidation at the metal center. Through careful tuning of the ligand scaffold, we have developed selective sensors for hypoxia and oxidative stress, showing promise for future applications for in vivo detection of these states in both cellular and animal disease models. New enhanced nanoparticle-based platforms based on metal-doped perfluorocarbons will also be discussed.

 

20190711_대학원특별세미나_Emily Que.pdf


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
70 [November 7. 2019] Student Host Colloquium/Unveiling cellular heterogeneity in early beige adipogenesis file Prof. DaeHee Hwang(Seoul National University) Thu. 7 November. 2019
69 [October 31. 2019] Engineering energy band structures in organic and hybrid semiconductor devices using non-conjugated polyelectrolyte films file Asst. Prof. Bright Walker(Kyung Hee University) Thu. 31 October. 2019
68 [October 15. 2019] A more sustainable chemistry with elemental sulfur file Dr. Thanh Binh Nguyen(Institut of Natural Product Chemistry) Tue. 15 October. 2019
67 [September 19. 2019] Monitoring photo-chemical reaction with Raman spectroscopy file Prof. Choi Han-Kyu (Kunsan National University) Thu. 19 September. 2019
66 [August 14. 2019] Principle of Semiconductor Quantum Cascade Laser and It’s Application to Chemical Gas Detection file Dr. Byeong-il Seo(Agency for Defense Development) Wed. 14 August. 2019
» [July 11. 2019] Coordination Chemistry in 19F Magnetic Resonance Imaging: Agents for Illuminating Biological Environments in Vitro and in Vivo file Prof. Emily Que(The University of Texas at Austin) Thu. 11 July. 2019
64 [May 30. 2019] Palladium-Catalyzed Deprotonative Arylation of Azaarylmethyl Derivatives file Prof. Byeong-Seon Kim (Gyeongsang National University) Thu. 30 May. 2019
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59 [April 25. 2019] Colorful World of Quantum Dots Prof. Sungjee Kim (Pohang University of Science & Technology) Thu. 25 Apr. 2019
58 [April 4. 2019] Rational Design of Solid-State Materials with Asymmetric Coordination Environment Prof. Kang Min Ok (Sogang University) Thu. 4 Apr. 2019
57 [March 28. 2019] NMR Structural Studies of engineered novel antimicrobial peptides Prof. Yongae Kim (Hankuk University of Foreign Studies) Thu. 28 Mar. 2019
56 [March 21, 2019] Nanomaterials Design for Energy Conversion and Storage Prof. Jong-Hyuk Park (Yonsei University) Thu. 21 Mar. 2019
55 [March 27, 2019] Hyperpolarization Researches with NV center, 129Xe and Parahydrogen file Prof. Keunhong Jeong March 27, 2019
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