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2017.03.31 13:39

[Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea

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Speaker Prof. Sangsu Bae
Date Thu. 23 Mar. 2017
Time 5:00pm
Venue #633, Asan Hall, College of Science

“Genome editing using CRISPR nucleases and its applications”

 

Genome editing with engineered nucleases such as ZFNs (zinc finger nucleases), TALENs (transcription-activator-like effector nucleases), and CRISPR-Cas9/Cpf1 endonucleases is broadly useful for biomedical research, biotechnology, and medicine. Unlike ZFNs and TALENs whose DNA specificities are determined by DNA-binding proteins, CRISPR nucleases use complementary base pairing to recognize target sites. Now, CRISPR nucleases are widely used due to the ease of use and inexpensive cost; researchers can induce gene editing at different sites by simply altering the guide RNAs. Here I present a web-based CRISPR design tool (www.rgenome.net), including a novel CRISPR design and a genome editing assessment tool. These tools are indispensable for gene mutation in human cells, animals and plants. Furthermore, I would like to introduce versatile applications of CRISPR nucleases such as one-step transformation of microalgae by DNA-free manners and the detailed mechanisms of Cas9-guide RNA complex revealed by single-molecule FRET assay.

 

Prof. Sangsu Bae

Department of Chemistry, Hanyang University, Seoul, South Korea

 


List of Articles
No. Subject Speaker Date
Notice Spring semester 2019 Seminar Schedule file - -
63 Fall semester 2018 Seminar Schedule file - -
62 Fall semester 2016 Seminar Schedule file - -
61 Spring semester 2017 Seminar Schedule file - -
60 [Fri. 17 Mar. 2017] 9th RINS Symposium file - Fri. 17 Mar. 2017
59 Fall semester 2017 Seminar Schedule file - -
58 [Thu. 27 Apr. 2017] Seminar was canceled! - -
57 [Wed. 5 July. 2017] Seminar is canceled! - -
56 7th Jilin-Korea-Waseda Alliance Annual Symposium file - August 17 ~ 19, 2017
55 [October 10, 2017] Novel Terahertz Spectroscopies file Director Mischa Bonn Tue, October 10, 2017
54 [October 25, 2017] Ultrafast electron microscopy: applications in chemical and materials sciences Dr. Byung-Kuk Yoo October 25, 2017
53 [March 5. 2019] Innovation@Agilent file Dr. Darlene Solomon (Agilent Technologies Inc.) Tuesday. 5 March. 2019
52 [May 16. 2019] Nano Structure Analysis by Synchrotron Small Angle X-ray Scattering Technique Dr. Hyungjoo-An (Pohang Accelerator Laboratory) Thu. 16 May. 2019
51 [Fri. 13 Oct. 2017] Dr. J. Nathan Hohman/The Molecular Foundry, Lawrence Berkeley National Laboratory, California, USA Dr. J. Nathan Hohman Fri. 13 Oct. 2017
50 [March 20, 2019] Challenges in molecular dynamics simulations of unfolded proteins and protein-DNA complexes file Dr. Jejoong Yoo March 20, 2019
49 [Thu. 26 Oct. 2017] Dr. Jung-Nyoung Heo/Center for Medicinal Chemistry Research, Korea Research Institute of Chemical Technology, Daejeon, Korea Dr. Jung-Nyoung Heo Thu. 26 Oct. 2017
48 [Thu. 13 Apr. 2017] Dr. Wan Ki Bae/Photoelectronic Hybrid Research Center, Korea Institute of Science and Technology, Seoul, Korea Dr. Wan Ki Bae Thu. 13 Apr. 2017
47 [Mon. 13 Oct. 2016] Prof. Amir H. Hoveyda/Multicomponent Catalytic Synthesis of Organoboron Compounds for Scalable Natural Product Synthesis Prof. Amir H. Hoveyda Monday 13 October 2016
46 [Thu. 11 May. 2017] Prof. Andreas Heinrich/IBS Research, Center for Quantum Nanoscience, Seoul, South Korea Prof. Andreas Heinrich Thu. 11 May. 2017
45 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
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