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2017.03.31 11:35

[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea

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Speaker Prof. Woon Ju Song
Date Thu. 9 Mar. 2017
Time 5:00pm
Venue #331, Asan Hall, College of Science

 “Inorganic Chemistry in Proteinaceous Environments”

 

Natural enzymes exhibit high catalytic efficiency and selectivity for their dedicated chemical transformations, and the power of enzyme catalysis has enticed chemists to scrutinize and mimic the chemical mechanism and reactivities. Particularly, a third of natural enzymes are found with metal ions, suggesting that inorganic elements are crucial in biological environments. From the studies of a natural enzyme, toluene/o-xylene monooxygenase hydroxylase, which belongs to the family of carboxylatebridged diiron proteins, we demonstrated that the diiron active site generates a catalytically reactive intermediate during dioxygen activation, and the protein environment functions as a sophisticatedly programmed matrix that regulates overall catalytic process. Inspired by the beauty of biochemical architectures associated with metal ions, we have designed a protein that self-assembles into a tetramer via hydrophobic interactions, disulfide bonds, and zinc coordination. The artificial protein yields catalytically active zinc-binding sites, which has been further optimized for molecular interactions with a substrate, ampicillin, by directed evolution. We have learned that design of artificial metalloenzyme can be considered as a distinctive route of reproducing and developing orchestrated chemical/biological events, and we suppose that protein engineering can aid us to develop efficient and sustainable biocatalysts and biomaterials in conjunction with synthetic biology, bioinformatics, and other related fields.

 

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Prof. Woon Ju Song

Department of Chemistry, Seoul National University, Seoul, Korea


List of Articles
No. Subject Speaker Date
Notice Spring semester 2017 Seminar Schedule file - -
33 [Wed. 5 July. 2017] Seminar was canceled! - -
32 [Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst file Prof. James Y. Hamilton Wednesday 28 December 2016
» [Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea Prof. Woon Ju Song Thu. 9 Mar. 2017
30 [Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits Prof. Yong-Young Noh Thursday 9 June 2016
29 [Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions Prof. Jaeyoung Sung Thursday 8 September 2016
28 [Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea Prof. Won-jin Chung Thu. 8 Jun. 2017
27 [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons Prof. Young S. Park Thursday 6 October 2016
26 [Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan Prof. Rong-Jie Chein Thu. 6 Apr. 2017
25 [Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea Prof. Jeong Ho Cho Thu. 30 Mar. 2017
24 [Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery Prof. Min-Sik Kim Thursday 3 November 2016
23 [Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension Prof. Tae-Young Yoon Thursday 29 September 2016
22 [Thu. 27 Apr. 2017] Seminar was canceled! - -
21 [Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction Prof. Sung June Cho Thursday 26 May 2016
20 [Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul Prof. Wonsuk Kim Thu. 25 May. 2017
19 [Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea Prof. Sangsu Bae Thu. 23 Mar. 2017
18 [Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions Prof. Anna Lee Thursday 22 September 2016
17 [Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy Prof. Chan Hyuk Kim Thursday 20 October 2016
16 [Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses Prof. Sunkyu Han Thursday 2 June 2016
15 [Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy Prof. Zhuang Liu Thursday 19 May 2016
14 [Thu. 18 May. 2017] Student Host Colloquium : 1,1-Bisborylalkane: New Class of Organoboron Compound for the Chemo, Regio and Stereoselective Organic Transformations Prof. Seung Hwan Cho Thu. 18 May. 2017
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