|Speaker||Prof. Rong-Jie Chein|
|Date||Thu. 6 Apr. 2017|
|Venue||#633, Asan Hall, College of Science|
“Hydroxy/Amine-Directed Ortho-Alkylation and Its Application
in Total Synthesis of Panduratin D”
Hydroxyl/amine-directed ortho-nucleophilic acyl alkylations of N,N-diethylarylamides have been developed using a simple reagent combination of LDA and chlorosilane. The
transformations involve: 1) a complex-induced proximity effect (CIPE) in the deprotonation step, 2) an intramolecular Peterson-type reaction of the resulting α-silyl carbanion with the amide group, and 3) fission of the final β-oxygenated/nitrogenated silyl intermediate. The study of the mechanism, as well as the application of the protocol to an anionic Hellwinkel-Snieckus-Fries rearrangement, a series of highly efficient functional group transformations, and a total synthesis of Panduratin D, a cytotoxic natural product against pancreatic cancer cells, are reported.
 H.-J. Lo, C.-Y. Lin, M.-C. Tseng, R.-J. Chein, Angew. Chem. Int. Ed. 2014, 53, 9026.
 C.-Y. Lin, M.-C. Tseng, R.-J. Chein, Synlett: SYNPACTS, 2014, 25, 2827–2830.
 I. F. Yu, R.-J. Chein, to be submitted.
 S. R. Bavikar, R.-J. Chein, to be submitted.
“Chiral Tetrahydrothiophene Ligands in Asymmetric Catalysis”
Chiral sulfur ligands are becoming a versatile tool in organic chemistry due to the
blossomed development achieved in the past years. This presentation describes an
expeditious and efficient preparation of enantiopure (thiolan-2-yl)diarylmethanols and
the applications of their derivatives to catalytic and asymmetric Corey-Chaykovsky
epoxidation,1 the imino Corey-Chaykovsky aziridination,2,3 as well as the first oxathiaborenium catalyzed asymmetric Diels-Alder reaction.4,5
1. Wu, H.-Y.; Chang, C.-W.; Chein, R.-J. J. Org. Chem. 2013, 78, 5788-5793.
2. Huang, M.-T.; H.-Y. Wu; Chein, R.-J. Chem. Commun. 2014, 50, 1101-1103.
3. Wang, S.-H.; Chein, R.-J. Tetrahedron, 2016, 72, 2607-2615.
4. Kumar, S. N.; Yu, I. F.; Chein, R.-J. Org. Lett. 2017, 19, 22-25. (Highlighted by C&EN 2017, 95(1), 9).
5. Tsai, M.-L.; Chein, R.-J. to be submitted.
Prof. Rong-Jie Chein
Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan
« Prev [Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular En...[Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular En... 2016.10.04by 〈
[Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institu... Next »[Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institu... 2017.03.31by 〉
|Notice||Spring semester 2017 Seminar Schedule||-||-|
|33||[Wed. 5 July. 2017] Seminar was canceled!||-||-|
|32||[Wed. 28 Dec. 2016] Prof. James Y. Hamilton/Development of a Broad Range of Asymmetric C–C Bond Forming Reactions with a Versatile Iridium Catalyst||Prof. James Y. Hamilton||Wednesday 28 December 2016|
|31||[Thu. 9 Mar. 2017] Prof. Woon Ju Song/Department of Chemistry, Seoul National University, Seoul, Korea||Prof. Woon Ju Song||Thu. 9 Mar. 2017|
|30||[Thu. 9 Jun. 2016] Prof. Yong-Young Noh/Development of Printed Large Area Organic Transistors and Integrated Circuits||Prof. Yong-Young Noh||Thursday 9 June 2016|
|29||[Thu. 8 Sep. 2016] Prof. Jaeyoung Sung/Stochastic chemical dynamics in living cells and its consequence for the control capacity of living cells over biological functions||Prof. Jaeyoung Sung||Thursday 8 September 2016|
|28||[Thu. 8 Jun. 2017] Prof. Won-jin Chung/Department of Chemistry, GIST, Gwangju, Republic of Korea||Prof. Won-jin Chung||Thu. 8 Jun. 2017|
|27||[Thu. 6 Oct. 2016] Prof. Young S. Park/Atomistic Molecular Engineering of Polycyclic Aromatic Hydrocarbons||Prof. Young S. Park||Thursday 6 October 2016|
|»||[Thu. 6 Apr. 2017] Prof. Rong-Jie Chein/Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan||Prof. Rong-Jie Chein||Thu. 6 Apr. 2017|
|25||[Thu. 30 Mar. 2017] Prof. Jeong Ho Cho/SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea||Prof. Jeong Ho Cho||Thu. 30 Mar. 2017|
|24||[Thu. 3 Nov. 2016] Prof. Min-Sik Kim/Mass spectrometry and its applications to Biological Discovery||Prof. Min-Sik Kim||Thursday 3 November 2016|
|23||[Thu. 29 Sep. 2016] Prof. Tae-Young Yoon/Observation of Single Membrane Proteins under Mechanical Tension||Prof. Tae-Young Yoon||Thursday 29 September 2016|
|22||[Thu. 27 Apr. 2017] Seminar was canceled!||-||-|
|21||[Thu. 26 Jun. 2016] Prof. Sung June Cho/Structural Elucidation of Novel Zeolite by Dual Space Approaches Using X-ray Powder Diffraction||Prof. Sung June Cho||Thursday 26 May 2016|
|20||[Thu. 25 May. 2017] Prof. Wonsuk Kim/Department of Chemistry and Nano Science, Ewha Womans University, Seoul||Prof. Wonsuk Kim||Thu. 25 May. 2017|
|19||[Thu. 23 Mar. 2017] Prof. Sangsu Bae/Department of Chemistry, Hanyang University, Seoul, South Korea||Prof. Sangsu Bae||Thu. 23 Mar. 2017|
|18||[Thu. 22 Sep. 2016] Prof. Anna Lee/Organocatalyzed Asymmetric Reactions||Prof. Anna Lee||Thursday 22 September 2016|
|17||[Thu. 20 Oct. 2016] Prof. Chan Hyuk Kim/Novel Small Molecule-based Approaches for Cancer Immunotherapy||Prof. Chan Hyuk Kim||Thursday 20 October 2016|
|16||[Thu. 2 Jun. 2016] Prof. Sunkyu Han/Total Syntheses of Complex Alkaloids Inspired by Biosynthetic Hypotheses||Prof. Sunkyu Han||Thursday 2 June 2016|
|15||[Thu. 19 May. 2016] Prof. Zhuang Liu/Nanotechnology for enhanced cancer radiation therapy and immunotherapy||Prof. Zhuang Liu||Thursday 19 May 2016|
|14||[Thu. 18 May. 2017] Student Host Colloquium : 1,1-Bisborylalkane: New Class of Organoboron Compound for the Chemo, Regio and Stereoselective Organic Transformations||Prof. Seung Hwan Cho||Thu. 18 May. 2017|
Designed by sketchbooks.co.kr / sketchbook5 board skin