Loading...
Photocatalytic Superoxide Radical Generator that Induces Pytoptosis in Cancer Cells
| author | Jong Seung Kim |
|---|---|
| Homepage | http://orgchem.korea.ac.kr/ |
| journal | Journal of the American Chemical Society |
In this study, we show that a photocatalytic superoxide radical (O2−•) generator, NI-TA, triggers pyroptosis in cancer cells. NI-TA was designed to take advantage of an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed that the pyroptosis triggered by NI-TA under conditions of photoexcitation proceeds through a caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). NI-TA was found to function via a partial-O2-recycling mode of action and to trigger cell pyroptosis and provide for effective cancer cell ablation even under conditions of hypoxia (≤2% O2). In the case of T47D 3D multicellular spheroids, good antitumor efficiency and stemness inhibition are achieved. This work highlights how photocatalytic chemistry may be leveraged to develop effective pyroptosis-inducing agents.
https://doi.org/10.1021/jacs.2c03256
« Prev Deep learning for development of organic optoelectronic devic...
Deep learning for development of organic optoelectronic devic...
2023.05.08by webmaster2
〈
Direct C-H metallation of tetrahydrofuran and application in ... Next »
Direct C-H metallation of tetrahydrofuran and application in ...
2023.05.08by webmaster2
〉
-
Read MoreNo Image
Self-Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
Hugh I. Kimhttps://www.hughkimlab.com/In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this process remain unclear. In the brains of AD patients, o...Date2023.12.20 Bywebmaster2 Views661 -
Read More
Ultranarrow Mid-infrared Quantum Plasmon Resonance of Self-Doped Silver Selenide Nanocrystal
Kwang Seob Jeonghttps://kwangsjeong.wixsite.com/ksjlab-koreaunivThe infrared quantum plasmon resonance (IR QPR) of nanocrystals (NCs) exhibits the combined properties of classical and quantum mechanics, potentially enabling unprecedented optics. However, research on the development of localized surface ...Date2023.12.20 Bywebmaster2 Views770 -
Read More
Molecular Thermoelectricity in EGaIn-Based Molecular Junctions
Hyo Jae Yoonhttps://hyojaeyoon.wixsite.com/ommlUnderstanding the thermoelectric effects that convert energy between heat and electricity on a molecular scale is of great interest to the nanoscience community. As electronic devices continue to be miniaturized to nanometer scales, thermor...Date2023.12.20 Bywebmaster2 Views813 -
Read More
Perovskite Nanocatalsts Protected by Hermetically Sealing for Highly Bright and Stable Deep-Blue Light-Emitting Diodes
Dong Hoon Choi, Kwangyeol Leehttp://nanolab.korea.ac.kr/Metal–halide perovskite nanocrystals (NCs) have emerged as suitablelight-emitting materials for light-emitting diodes (LEDs) and other practicalapplications. However, LEDs with perovskite NCs undergoenvironment-induced and ion-migratio...Date2023.07.04 Bywebmaster2 Views166 -
Read More
The importance of a charge transfer descriptor for screening potential CO2 reduction on electrocatalysts
Stefan Ringehttps://ringelab.com/It has been over twenty years since the linear scaling of reaction intermediate adsorption energies started to coin the fields of heterogeneous and electrocatalysis as a blessing and a curse at the same time. It has established the possibil...Date2023.07.04 Bywebmaster2 Views171 -
Read More
Resonant Raman-Active Polymer Dot Barcodes for Multiplex Cell Mapping
Sang-Hee Shim, Han Young Woohttps://www.ooml.korea.ac.kr/Resonance Raman spectroscopy is an efficient tool for multiplex imaging because of the narrow bandwidth of the electronically enhanced vibrational signals. However, Raman signals are often overwhelmed by concurrent fluorescence. In this stu...Date2023.05.08 Bywebmaster2 Views206 -
Read More
Decoding the Roles of Amyloid-β (1-42)'s Key Oligomerization Domains toward Designing Epitope-Specific Aggregation Inhibitors
Hugh I. Kimhttps://www.hughkimlab.com/Fibrillar amyloid aggregates are the pathological hallmarks of multiple neurodegenerative diseases. The amyloid-β (1-42) protein, in particular, is a major component of senile plaques in the brains of patients with Alzheimer’s dis...Date2023.05.08 Bywebmaster2 Views1677 -
Read More
Flattening bent Janus nanodiscs expands lattice parameters
Kwangyeol Leehttp://ChemNanoscale lattice parameter engineering is a potentially powerful tool for tailoring the electronic properties of nanomaterials. The nascent strain in juxtaposed hetero-interfaces of nanocrystals was recently shown to substantially affect th...Date2023.05.08 Bywebmaster2 Views142 -
Read More
Directing the surface atomic geometry on copper sulfide for enhanced electrochemical nitogen reduction
Kwangyeol Leehttp://nanolab.korea.ac.kr/Understanding catalytic-conversion determinants will blueprint an efficient electrocatalyst design for electrochemical nitrogen reduction. In metal chalcogenide-based catalysts, metal-site nitrogen adsorption initiates nitrogen fixation, and...Date2023.05.08 Bywebmaster2 Views155 -
Read More
High Seebeck Coefficient Achieved by Multinuclear Organometallic Molecular Junctions
Hyo Jae Yoonhttps://hyojaeyoon.wixsite.com/ommlThis paper describes thermoelectric property of molecular junctions incorporating multinuclear ruthenium alkynyl complexes that comprise Ru(dppe)2 (dppe = 1,2-bis(diphenylphosphino)ethane) fragments and diethylnyl aromatic bridging ligands w...Date2023.05.08 Bywebmaster2 Views186 -
Read More
Thermopower in Transition from Tunneling to Hopping
Hyo Jae Yoonhttps://hyojaeyoon.wixsite.com/ommlThe Seebeck effect of molecular junction in a hopping regime or tunneling-to-hopping transition remains uncertain. This paper describes the Seebeck effect in molecular epitaxy films (OPIn where n = 1 – 9) based on imine condensation be...Date2023.05.08 Bywebmaster2 Views161 -
Read More
An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO-) in the Alzheimer's Disease Brain
Jong Seung Kimhttp://orgchem.korea.ac.kr/Peroxynitrite (ONOO-) plays a critical role in Alzheimer's disease (AD), and the association between ONOO- and AD is inexplicit. To reveal the ONOO- influxes in AD brains, an activatable activity-based fluorescence probe Rd-DPA3 was rati...Date2023.05.08 Bywebmaster2 Views189 -
Read More
Deep learning for development of organic optoelectronic devices: Efficient prescreening of hosts and emitters in deep-blue fluorescent OLEDS
Dong Hoon Choi and Sungnam Parkhttps://ultrafastspec.wixsite.com/sparkThe highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies, which are key factors in optoelectronic devices, must be accurately estimated for newly designed materials. Here, we developed a deep lear...Date2023.05.08 Bywebmaster2 Views171 -
Read More
Photocatalytic Superoxide Radical Generator that Induces Pytoptosis in Cancer Cells
Jong Seung Kimhttp://orgchem.korea.ac.kr/In this study, we show that a photocatalytic superoxide radical (O2−•) generator, NI-TA, triggers pyroptosis in cancer cells. NI-TA was designed to take advantage of an intramolecular triplet-ground state splitting energy modulati...Date2023.05.08 Bywebmaster2 Views217 -
Read More
Direct C-H metallation of tetrahydrofuran and application in flow
Heejin Kimhttps://gowithflow.wixsite.com/hkimThe direct C–H metallation of tetrahydrofuran (THF) to generate α-anionic THF is one of the most straightforward methods for the the generation and utilization of α-anionic THF. Here we develop a reaction for the direct met...Date2023.05.08 Bywebmaster2 Views155 -
Read More
Functionalization of Diamine-Appended MOF-Based Adsorbents by Ring Opening of Epoxide: Long-Term Stability and CO2 Recyclability under Humid Conditions
Chang Seop Honghttps://www.immlab.korea.ac.kr/Although diamine-appended metal-organic framework (MOF) adsorbents exhibit excellent CO2 adsorption performance, a continuous decrease in long-term capacity during repeated wet cycles remains a formidable challenge for practical applications...Date2023.05.08 Bywebmaster2 Views192 -
Read More
High Gravimetric and Volumetric Ammonia Capacities in Robust Metal-Organic Frameworks Prepared via Double Postsynthetic Modification
Chang Seop Honghttps://www.immlab.korea.ac.kr/Ammonia is a promising energy vector that can store the high energy density of hydrogen. For this reason, numerous adsorbents have been investigated as ammonia storage materials, but ammonia adsorbents with a high gravimetric/volumetric ammo...Date2023.05.08 Bywebmaster2 Views189 -
Read More
Li-ion Intercalation, Rectification, and Solid Electrolyte Interphase in Molecular Tunnel Junctions
Hyo Jae Yoonhttps://hyojaeyoon.wixsite.com/ommlThis paper describes Li-ion intercalation into pyrenyl terminated self-assembled monolayer (SAM) on gold, inspired from graphite anode in Li-ion battery, and its effect on tunneling performance in molecular junction incorporating the SAM. As...Date2023.05.08 Bywebmaster2 Views132 -
Read More
Thermopower of Molecular Junction in Harsh Thermal Environments
Hyo Jae Yoonhttps://hyojaeyoon.wixsite.com/ommlMolecular junctions can be miniaturized devices for heat-to-electricity conversion application, yet these operate only in mild thermal environments (less than 323 K) because thiol, the most widely used anchor moiety for chemisorption of acti...Date2023.05.08 Bywebmaster2 Views139 -
Read More
Microfluidics-Assisted Synthesis of Hierarchical Cu2O Nanocrystal as C2-Selective CO2 Reduction Electrocatalyst
Heejin Kim, Kwangyeol Leehttp://nanolab.korea.ac.kr/Copper-based catalysts have attracted enormous attention due to their high selectivity for C2+ products during the electrochemical reduction of CO2 (CO2RR). In particular, grain boundaries on the catalysts contribute to the generation of var...Date2023.05.08 Bywebmaster2 Views165
Designed by sketchbooks.co.kr / sketchbook5 board skin